Characterisation of tumour vasculature in mouse brain by USPIO contrast-enhanced MRI
| Autor: | O. van Tellingen, C.N. Maass, A.J. van der Kogel, William P.J. Leenders, Arend Heerschap, Giulio Gambarota, Pieter Wesseling |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Gadolinium DTPA
Cancer Research Pathology Relaxation Angiogenesis Melanoma Experimental Contrast Media Vascular permeability Blood volume Aetiology screening and detection [ONCOL 5] Metastases Agent 030218 nuclear medicine & medical imaging Mice 0302 clinical medicine Gliomas U87 Magnetite Nanoparticles Melanoma Molecular diagnosis prognosis and monitoring [UMCN 1.2] Cancer Blood Volume medicine.diagnostic_test Progression Brain Neoplasms Dextrans Oxides Human brain Glioma contrast agent Magnetic Resonance Imaging VEGF Mitochondrial medicine [IGMD 8] medicine.anatomical_structure Oncology mouse brain Chemical and physical biology [NCMLS 7] medicine.medical_specialty Energy and redox metabolism [NCMLS 4] Gd-DTPA Iron Transplantation Heterologous Blood-Volume Capillary Permeability 03 medical and health sciences Translational research [ONCOL 3] medicine Animals Humans business.industry tumour Improved Delineation Magnetic resonance imaging Tissue engineering and pathology [NCMLS 3] medicine.disease Image Enhancement USPIO Ferrosoferric Oxide Tumor microenvironment [UMCN 1.3] Functional Imaging [UMCN 1.1] high-field MR business Translational Therapeutics 030217 neurology & neurosurgery Neoplasm Transplantation Immunity infection and tissue repair [NCMLS 1] |
| Zdroj: | British Journal of Cancer British Journal of Cancer, 98, 11, pp. 1784-9 British Journal of Cancer, 98, 1784-9 |
| ISSN: | 0007-0920 |
| Popis: | Contains fulltext : 69755.pdf (Publisher’s version ) (Closed access) To enhance the success rate of antiangiogenic therapies in the clinic, it is crucial to identify parameters for tumour angiogenesis that can predict response to these therapies. In brain tumours, one such parameter is vascular leakage, which is a response to tumour-derived vascular endothelial growth factor-A and can be measured by Gadolinium-DTPA (Gd-DTPA)-enhanced magnetic resonance imaging (MRI). However, as vascular permeability and angiogenesis are not strictly coupled, tumour blood volume may be another potentially important parameter. In this study, contrast-enhanced MR imaging was performed in three orthotopic mouse models for human brain tumours (angiogenic melanoma metastases and E34 and U87 human glioma xenografts) using both Gd-DTPA to detect vascular leakage and ultrasmall iron oxide particles (USPIO) to measure blood volume. Pixel-by-pixel maps of the enhancement in the transverse relaxation rates (Delta R(2) and Delta R(2)(*)) after injection of USPIO provided an index proportional to the blood volume of the microvasculature and macrovasculature, respectively, for each tumour. The melanoma metastases were characterised by a blood volume and vessel leakage higher than both glioma xenografts. The U87 glioblastoma xenografts displayed higher permeability and blood volume in the rim than in the core. The E34 glioma xenografts were characterised by a relatively high blood volume, accompanied by only a moderate blood-brain barrier disruption. Delineation of the tumour was best assessed on post-USPIO gradient-echo images. These findings suggest that contrast-enhanced MR imaging using USPIOs and, in particular, Delta R(2) and Delta R(2)(*) quantitation, provides important additional information about tumour vasculature. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|