Neonatal experience interacts with adult social stress to alter acute and chronic Theiler’s virus infection
| Autor: | Mary W. Meagher, C.J.R. Welsh, Robin Johnson, Andrew J. Steelman, F. Rassu, Thomas H. Welsh, Colin R. Young, Thomas W. Prentice, S. Maldonado Bouchard, P. Bridegam |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Immunology Disease Motor Activity Handling Psychological Virus Mice Behavioral Neuroscience chemistry.chemical_compound Myelin Theilovirus Corticosterone Cardiovirus Infections medicine Animals Social Behavior Interleukin 6 Social stress Mice Inbred BALB C biology Interleukin-6 Endocrine and Autonomic Systems business.industry Multiple sclerosis Age Factors medicine.disease medicine.anatomical_structure Animals Newborn chemistry Acute Disease Chronic Disease biology.protein Antibody business Myelin Proteins Stress Psychological |
| Zdroj: | Brain, Behavior, and Immunity. 40:110-120 |
| ISSN: | 0889-1591 |
| DOI: | 10.1016/j.bbi.2014.03.002 |
| Popis: | Previous research has shown that neonatal handling has prolonged protective effects associated with stress resilience and aging, yet little is known about its effect on stress-induced modulation of infectious disease. We have previously demonstrated that social disruption stress exacerbates the acute and chronic phases of the disease when applied prior to Theiler's virus infection (PRE-SDR) whereas it attenuates disease severity when applied concurrently with infection (CON-SDR). Here, we asked whether neonatal handling would protect adult mice from the detrimental effects of PRE-SDR and attenuate the protective effects of CON-SDR on Theiler's virus infection. As expected, handling alone decreased IL-6 and corticosterone levels, protected the non-stressed adult mice from motor impairment throughout infection and reduced antibodies to myelin components (PLP, MBP) during the autoimmune phase of disease. In contrast, neonatal handling X PRE/CON-SDR elevated IL-6 and reduced corticosterone as well as increased motor impairment during the acute phase of the infection. Neonatal handling X PRE/CON-SDR continued to exacerbate motor impairment during the chronic phase, whereas only neonatal handling X PRE-SDR increased in antibodies to PLP, MOG, MBP and TMEV. Together, these results imply that while handling reduced the severity of later Theiler's virus infection in non-stressed mice, brief handling may not be protective when paired with later social stress. |
| Databáze: | OpenAIRE |
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