The impact of macroautophagy on CD8 + T-cell-mediated antiviral immunity

Autor: Matthew L. Albert, Brieuc Perot, Molly A. Ingersoll
Přispěvatelé: Immunobiologie des Cellules Dendritiques, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), B. P. P. has received funding from Allocation doctorales Canceropole Ile-de-France. M. A. I. has received funding from the European Union Seventh Framework Programme Marie Curie Action under grant agreement no. [PCIG11-GA-2012-322117] and the Immuno-Oncology Labex. M. L. A. has received support from the European Research Council (ERC), the French National Cancer Institute (INCa) and La Ligue contre le cancer., The authors thank Monique Gannage and Pierre-Emmanuel Joubert for critical reading of the manuscript, European Project: 322117,EC:FP7:PEOPLE,FP7-PEOPLE-2012-CIG,UPECBCG(2013), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Epitopes
T-Lymphocyte
MESH: Virus Diseases/immunology
CD8-Positive T-Lymphocytes
Lymphocyte Activation
MESH: CD8-Positive T-Lymphocytes/immunology
0302 clinical medicine
T-Lymphocyte Subsets
Immunology and Allergy
MESH: Animals
MESH: Viruses/immunology
Antigens
Viral
MESH: CD8-Positive T-Lymphocytes/metabolism
MESH: Cross-Priming/immunology
0303 health sciences
MESH: Epitopes
T-Lymphocyte/immunology
MESH: Autophagy/immunology
Acquired immune system
3. Good health
Cell biology
Virus Diseases
Viruses
[SDV.IMM]Life Sciences [q-bio]/Immunology
MESH: Immunity
Innate
MESH: Virus Diseases/metabolism
MESH: Antigen Presentation/immunology
Immunology
Antigen presentation
virus
Biology
Major histocompatibility complex
03 medical and health sciences
Immune system
Cross-Priming
Antigen
MESH: T-Lymphocyte Subsets/immunology
MHC class I
MESH: Antigens
Viral/immunology
Autophagy
Animals
Humans
030304 developmental biology
Innate immune system
MESH: Humans
CD8+ T lymphocytes
Immunity
Innate
MESH: Lymphocyte Activation/immunology
macroautophagy
antigen presentation
biology.protein
030215 immunology
Zdroj: Immunological Reviews
Immunological Reviews, 2013, Special Issue: Immunity to Viruses 255 (1), pp.40-56. ⟨10.1111/imr.12096⟩
Immunological Reviews, Wiley, 2013, Special Issue: Immunity to Viruses 255 (1), pp.40-56. ⟨10.1111/imr.12096⟩
ISSN: 0105-2896
1600-065X
DOI: 10.1111/imr.12096⟩
Popis: International audience; Macroautophagy is a catabolic recycling pathway, which can be induced by various stress stimuli. Viruses are able to manipulate autophagy in the cells that they infect. The impact of autophagy on the innate immune response to viruses and its stimulatory role in antigen presentation to CD4(+) T cells are well documented. Herein, we present the impact of autophagy on the activation of cytotoxic T lymphocyte (CTL)-mediated antiviral immune responses, which are required for the eradication or control of multiple viruses. We first discuss the general mechanisms by which viruses can either induce or block autophagy in cells. We then explore the cross-talk between autophagy and innate immune processes, which are both first line defenses against viruses; and constitute crucial steps for the initiation of potent adaptive immune responses. We describe the impact of autophagy on the presentation of viral peptide antigens on class I major histocompatibility complex (MHC I), a prerequisite for the priming of CTL responses. In sum, our review highlights the interplay between viruses and three integrated host response pathways - autophagy, innate and adaptive immunity - providing a framework for future mechanistic and pathogenesis-based research.
Databáze: OpenAIRE
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