Impaired quality of life after chikungunya virus infection: a 2-year follow-up study
| Autor: | Henriette de Valk, Lucie Léon, Francis Guillemin, Marie Mura, Véronique Vaillant, M.-J. Letort, Jean-Marc Virion, Elisabeth Couturier, Fabrice Simon |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent SF-36 Population Disability Evaluation Young Adult Rheumatology Quality of life Surveys and Questionnaires Internal medicine Humans Medicine Disabled Persons Pharmacology (medical) Young adult Child education Aged Retrospective Studies Aged 80 and over education.field_of_study Alphavirus Infections business.industry Retrospective cohort study Middle Aged Prognosis medicine.disease Comorbidity Population Surveillance Quality of Life Physical therapy Chikungunya Fever Female France Morbidity General Health Questionnaire business Chikungunya virus Follow-Up Studies Cohort study |
| Zdroj: | Rheumatology. 51:1315-1322 |
| ISSN: | 1462-0332 1462-0324 |
| Popis: | OBJECTIVES: To measure the frequency of and risk factors for rheumatic manifestations after chikungunya virus (CHIKV) infection and to assess their impact on quality of life (QoL). METHODS: In a cohort study among 509 cases diagnosed in France, demographic and clinical characteristics were collected at baseline, and QoL status by 36-item short-form health survey (SF-36), a short form of the Arthritis Impact Measurement Scales 2 (AIMS2-SF) and General Health Questionnaire (GHQ-12) at follow-up. SF-36 scores were compared with population norms. Factors associated with QoL were identified in multivariate linear regression models. RESULTS: A total of 391 (77%) patients participated (53.5% female, mean age 50.2 years). Median time from onset at follow-up was 23.4 months. Among 176 recovered patients, a shorter duration of symptoms was observed in younger age groups and male patients. The probability of full recovery at 1 year was 0.39. Those not recovered were older, had more comorbidities and a longer acute stage with joint swelling. Scores of physical and mental components of the SF-36 and GHQ-12 were low. The AIMS2-SF was affected mainly in symptoms, psychological and social dimensions. Recovered patients did not differ significantly from age- and gender-matched population SF-36 norms. Older age (P = 0.01-0.002) was associated with lower SF-36 scores. Other factors associated with lower SF-36, lower GHQ12 scores and higher AIMS2-SF dimensions were lack of recovery (P = 0.017 to |
| Databáze: | OpenAIRE |
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