Pharmacokinetics of florfenicol in veal calves
| Autor: | K.J. Varma, J. D. Powers, Powers Te, J. F. Lamendola, P. E. Adams |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Thiamphenicol
Pharmacology Florfenicol Volume of distribution General Veterinary Metabolic Clearance Rate Chemistry Administration Oral Biological Availability Absorption (skin) Urine Intestinal absorption Kinetics chemistry.chemical_compound Intestinal Absorption Pharmacokinetics Oral administration Injections Intravenous Animals Cattle Female Median body |
| Zdroj: | Journal of Veterinary Pharmacology and Therapeutics. 9:412-425 |
| ISSN: | 1365-2885 0140-7783 |
| DOI: | 10.1111/j.1365-2885.1986.tb00062.x |
| Popis: | The pharmacokinetic disposition of florfenicol was described in veal calves after administration of a single 22-mg/kg dose intravenously, orally after a 12-h fast and orally 5 min post feeding. Both serum concentrations and urinary excretion were studied. After intravenous administration the median elimination half-life was 171.9 min while the half-life of the distribution phase was 5.9 min. The median body clearance (Cl) and apparent volume of distribution (Vz) were 2.85 ml/kg/min and 0.78 l/kg, respectively. Following oral administration the median bio-availability (f) was 0.88 for calves dosed after a 12-h fast and 0.65 for calves dosed 5 min post feeding. Calves given the oral doses had a complex absorption pattern with delayed absorption. Slightly more than 50% of the administered dose both orally and intravenously was recovered as unchanged florfenicol in the urine by 30 h. |
| Databáze: | OpenAIRE |
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