Low mannose-binding lectin levels andMBL2gene polymorphisms associate withChlamydia pneumoniaeantibodies
| Autor: | Ari Peitso, Olli Vainio, Pekka Saikku, Aini Bloigu, Maija Leinonen, Sylvi Silvennoinen-Kassinen, Raija Juvonen, Mika Paldanius, Aino Rantala, Taina K. Lajunen |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Adolescent Genotype Immunology Single-nucleotide polymorphism Mannose-Binding Lectin Polymorphism Single Nucleotide Microbiology Antibodies Young Adult Exon Gene Frequency Risk Factors medicine Humans Allele Chlamydophila Infections Molecular Biology Finland Mannan-binding lectin Chlamydia biology Lectin Cell Biology Chlamydophila pneumoniae medicine.disease Molecular biology Immunoglobulin A Military Personnel Infectious Diseases Immunoglobulin M Immunoglobulin G biology.protein Antibody |
| Zdroj: | Innate Immunity. 17:35-40 |
| ISSN: | 1753-4267 1753-4259 |
| Popis: | Objective: Mannose-binding lectin (MBL) has been shown to inhibit infection of host cells by Chlamydia pneumoniae in vitro. We studied if MBL levels and MBL2 polymorphisms associate with the presence of C. pneumoniae antibodies in vivo.Materials and Methods: Single nucleotide polymorphisms (SNPs) of the MBL2 gene (promoter alleles H/L, X/Y and P/Q; and exon 1 variant alleles B, C and D and wild-type allele A) were genotyped and serum MBL concentrations and C. pneumoniae IgG, IgA and IgM antibodies were analysed in 889 Finnish military recruits.Results: An MBL level below the median concentration and the MBL2 P/P genotype were significant risk factors of IgG or IgA seroconversions or the presence of IgM antibodies during military service (adjusted odds ratio (OR) 1.5; 95% confidence interval (CI) 1.1—2.1 and OR 1.5; 95% CI 1.0—2.2, respectively). In addition, the promoter Y/Y (OR 1.6; 95% CI 1.1—2.3) and exon 1 variant allele genotypes (OR 1.4; 95% CI 1.0—2.0) were possibly associated with elevated antibodies.Conclusions: These results suggest, for the first time, that low serum MBL levels and MBL2 polymorphisms may associate with elevated C. pneumoniae antibodies and seroconversions and thus support the previous findings in vitro. |
| Databáze: | OpenAIRE |
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