Antioxidant and α-Glucosidase Inhibitory Constituents from Hornstedtia Species of Malaysia
| Autor: | Intan Safinar Ismail, Siti Ernieyanti Hashim, Siti Nurulhuda Matsuki, Hasnah Mohd Sirat, Khong Heng Yen |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
food.ingredient
Antioxidant DPPH medicine.medical_treatment Plant Science Antioxidants chemistry.chemical_compound food Picrates Zingiberaceae Drug Discovery medicine Glycoside Hydrolase Inhibitors α glucosidase inhibitory IC50 Pharmacology Chloroform Traditional medicine biology α glucosidase Biphenyl Compounds Malaysia alpha-Glucosidases General Medicine biology.organism_classification Plant Leaves Complementary and alternative medicine chemistry Biochemistry Hornstedtia |
| Zdroj: | Natural Product Communications. 10:1934578X1501000 |
| ISSN: | 1555-9475 1934-578X |
| DOI: | 10.1177/1934578x1501000919 |
| Popis: | Seven compounds were isolated from the n-hexane and chloroform extracts of the flowers and leaves of four Hornstedtia species and their structures were identified using spectroscopic techniques as 3,7,4′-trimethylkaempferol (1), 3,7-dimethylkaempferol (2), 7,4′-dimethylkaempferol (3), 3,5-dimethylkaempferol (4), 3-methylkaempferol (5), stigmast-4-en-3-one (6), and 6-hydroxy-stigmast-4-en-3-one (7). Compounds 1 to 7 were isolated from these species for the first time. They were assayed for free radical scavenging and α-glucosidase inhibition activities. The DPPH assay showed that 3-methylkaempferol (5) was the most potent antioxidant agent with an IC50 value 78.6 μM, followed by 7,4′-dimethylkaempferol (3) (IC50 = 86.1 μM). For α-glucosidase inhibition activity, 3-methylkaempferol (5) exhibited significant inhibitory activity with an IC50 value 21.0 μM. The present study revealed that Hornstedtia species have potential activities as antioxidant and α-glucosidase inhibitors. |
| Databáze: | OpenAIRE |
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