Understanding Patient Experience in Biliary Tract Cancer: A Qualitative Patient Interview Study
| Autor: | Chad Gwaltney, Xandra Lie, Afsaneh Barzi, Melinda Bachini, Oren Meyers, Makoto Ueno, Nana Rokutanda, Teresa Macarulla, Nikunj Patel, Christina Workman, G. Cohen, Davide Melisi, Seung Tae Kim |
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| Přispěvatelé: | Institut Català de la Salut, [Patel N] AstraZeneca, 1 Medimmune Way, Gaithersburg, MD 20878, USA. [Lie X] IQVIA, Amsterdam, The Netherlands . [Gwaltney C] Gwaltney Consulting, Westerly, RI, USA. [Rokutanda N] Cohen AstraZeneca, Gaithersburg, MD, USA. [Barzi A] City of Hope Comprehensive Cancer Center, Duarte, CA, USA. [Melisi D] Digestive Molecular Clinical Oncology Unit, Università degli Studi di Verona, Verona, Italy. Experimental Cancer Medicine Unit, Azienda Ospedaliera Integrata di Verona, Verona, Italy. [Macarulla T] Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Abdominal pain
medicine.medical_specialty Health Policy Planning and Management::Health Administration::Health Evaluation [PUBLIC HEALTH] Pacients - Satisfacció Disease Affect (psychology) Quality of life Qualitative research Patient experience Medicine neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias del tracto biliar [ENFERMEDADES] Original Research ambiente y salud pública::salud pública::medidas epidemiológicas::demografía::estado de salud::calidad de vida [ATENCIÓN DE SALUD] Biliary tract cancer business.industry Cognition Interview study Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Biliary Tract Neoplasms [DISEASES] Políticas Planificación y Administración en salud::administración en salud::evaluación en salud [SALUD PÚBLICA] Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Health Status::Quality of Life [HEALTH CARE] Oncology Tracte biliar - Càncer Physical therapy medicine.symptom business Qualitat de vida - Avaluació |
| Zdroj: | Scientia Oncology and Therapy |
| Popis: | Cáncer del tracto biliar; Estudio de entrevista; Investigación cualitativa Càncer del tracte biliar; Estudi d'entrevista; Recerca qualitativa Biliary tract cancer; Interview study; Qualitative research Introduction Patients living with biliary tract cancer (BTC) experience a decline in health-related quality of life (HRQoL). This study aimed to obtain a comprehensive understanding of the patient experience of BTC-related signs/symptoms and the impacts of these on daily functioning and HRQoL. Methods Patients with BTC participated in qualitative semi-structured concept elicitation interviews. Signs/symptoms and impacts of BTC were initially explored by targeted literature searches and interviews with five clinicians. Patient interviews were transcribed and coded using qualitative research software. Concept saturation was assessed over five interview waves. A sign/symptom or impact was defined as “salient” if mentioned by ≥ 50% of patients, with a mean disturbance rating of ≥ 5 (0–10 scale). A conceptual model of the patient experience of BTC-related signs/symptoms and impacts was produced. Results Twenty-three patients from the USA (78% women; median age: 54 years), diagnosed as having early (n = 3), locally advanced (n = 11) or metastatic (n = 9) disease, were interviewed. Sixty-six signs/symptoms and 12 impacts were identified. Of these, 46 signs/symptoms and 8 impacts were not identified from the targeted literature or clinician interviews. Concept saturation was reached by the fourth of five interview waves. Fourteen disease-related signs/symptoms (including fatigue/lack of energy, abdominal pain, lack of appetite, insomnia and diarrhoea) and three impacts (physical, emotional and cognitive impacts) were deemed “salient”. The conceptual model included 50 signs/symptoms and 12 impacts. Conclusion Patients with BTC reported a range of signs/symptoms and impacts that negatively affect daily functioning and HRQoL. This project was funded by AstraZeneca, Gaithersburg, MD, USA. Research and publication fees are funded by the study sponsor. |
| Databáze: | OpenAIRE |
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