Assessment of Protective Effects of Pheniramine Maleate on Reperfusion Injury in Lung After Distant Organ Ischemia
| Autor: | Ufuk Yetkin, Ismail Yurekli, Ismail Safa Satoglu, Muge Kiray, Banu Sarer Yurekli, Serkan Gur, Gamze Gokalp, Orhan Gokalp, Murat Aksun, Alper Bagriyanik, Ali Gürbüz |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Pheniramine Maleate Anti-Inflammatory Agents Ischemia Lung injury Methylprednisolone Rats Sprague-Dawley chemistry.chemical_compound Malondialdehyde Internal medicine medicine Animals Lung chemistry.chemical_classification Glutathione Peroxidase Pheniramine Superoxide Dismutase business.industry Glutathione peroxidase Lung Injury General Medicine medicine.disease Rats Disease Models Animal Endocrinology Lower Extremity chemistry Cytoprotection Reperfusion Injury Anesthesia Histamine H1 Antagonists Surgery Lipid Peroxidation Cardiology and Cardiovascular Medicine business Reperfusion injury medicine.drug |
| Zdroj: | Vascular and Endovascular Surgery. 47:219-224 |
| ISSN: | 1938-9116 1538-5744 |
| DOI: | 10.1177/1538574413475885 |
| Popis: | Objective: The aim of this study is to investigate the protective effects of methylprednisolone (MP) and pheniramine maleate (PM) on reperfusion injury of lungs developing after ischemia of the left lower extremity of rats. Materials and methods: A total of 28 randomly selected male rats were divided into 4 groups, each consisting of 7 rats. Group 1 was the control group. Group 2 was the sham group (ischemia/reperfusion [I/R]). Rats in group 3 were subjected to I/R and given PM (Ph group) and rats in group 4 were subjected to I/R and given MP (Pn group). Results: Malondialdehyde levels were significantly lower in Ph group than in I/R group ( P < .05). Superoxide dismutase and glutathione peroxidase enzyme activities were found to be significantly higher in Ph group than in the I/R group ( P < .05). Histological examination demonstrated that PM had protective effects against I/R injury. Conclusions: The PM has a protective effect against I/R injury in rat lung. |
| Databáze: | OpenAIRE |
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