Delayed introduction of immunosuppressive regimens in critically ill patients after liver transplantation
| Autor: | Wei-dong Duan, Zhi-Ming Zhao, Xian-jie Shi, Ying Luo, Wenbin Ji |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Critical Illness T-Lymphocytes medicine.medical_treatment 030230 surgery Immune monitoring Liver transplantation Gastroenterology 03 medical and health sciences Adenosine Triphosphate 0302 clinical medicine Immunity Internal medicine medicine Humans Gamma-glutamyltransferase Aged Hepatology biology Critically ill business.industry Organ dysfunction Immunosuppression gamma-Glutamyltransferase Middle Aged Liver Transplantation Transplantation Immunology biology.protein Female 030211 gastroenterology & hepatology medicine.symptom business Immunosuppressive Agents |
| Zdroj: | Hepatobiliary & Pancreatic Diseases International. 16:487-492 |
| ISSN: | 1499-3872 |
| DOI: | 10.1016/s1499-3872(17)60050-x |
| Popis: | Background The manipulation of immunosuppression therapy remains challenging in patients who develop infectious diseases or multiple organ dysfunction after liver transplantation. We evaluated the outcomes of delayed introduction of immunosuppression in the patients after liver transplantation under immune monitoring with ImmuKnow assay. Methods From March 2009 to February 2014, 225 consecutive liver recipients in our institute were included. The delayed administration of immunosuppressive regimens was attempted in 11 liver recipients with multiple severe comorbidities. Results The median duration of non-immunosuppression was 12 days (range 5–58). Due to the infectious complications, the serial ImmuKnow assay showed a significantly low ATP level of 64±35 ng/mL in the early period after transplantation. With the development of comorbidities, the ImmuKnow value significantly increased. However, the acute allograft rejection developed when a continuous distinct elevation of both ATP and glutamyltranspeptidase levels was detected. The average ATP level measured just before the development of acute rejection was 271±115 ng/mL. Conclusions The delayed introduction of immunosuppressive regimens is safe and effective in management of critically ill patients after liver transplantation. The serial ImmuKnow assay could provide a reliable depiction of the dynamics of functional immunity throughout the clinical course of a given patient. |
| Databáze: | OpenAIRE |
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