Transcriptome sequencing of melanocytic nevi and melanomas from Grm1 transgenic mice to determine melanoma driver mutations

Autor:	Anja K. Bosserhoff, Manfred Kunz, Miriam M. de Jel, Silke Kuphal, Julia C. Engelmann, Susanne Schiffner
Rok vydání:	2014
Předmět:	Neuroblastoma RAS viral oncogene homolog Mutation rate Nevi and melanomas Skin Neoplasms DNA Mutational Analysis Mice Transgenic Dermatology Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Mice medicine Nevus Animals Allele neoplasms Gene Melanoma Mutation Nevus Pigmented medicine.disease digestive system diseases Oncology Cancer research Transcriptome
Zdroj:	Pigment cellmelanoma research. 27(4)
ISSN:	1755-148X
Popis:	Malignant melanoma is thought to exhibit a high base mutation rate compared with other solid tumors. Therefore, there is a strong interest in discovering new mutations and understanding their impact on melanoma pathogenesis. Mutations in several genes such as BRAF, NRAS or KIT are associated with melanoma development and progression. The most common BRAF mutation, BRAF V600E, results in the constitutive activation of MAPK/ERK signaling in the tumor cells affecting cell division and differentiation. Moreover, previous studies have shown that allele variations of the CDKN2A gene and OCA2 gene are associated with melanoma susceptibility.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6645a5b07f9e8edee6d95758f89ed7 https://pubmed.ncbi.nlm.nih.gov/24661573 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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