Pharmacological treatments for cutaneous manifestations of inherited ichthyoses
| Autor: | Sergio Alcalá-Alcalá, Gerardo Leyva-Gómez, María L Del Prado-Audelo, Octavio D Reyes-Hernández, Maykel González-Torres, Hernán Cortés, Manuel González-Del Carmen, Zaida Urbán-Morlán |
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| Rok vydání: | 2019 |
| Předmět: |
Skin barrier
medicine.medical_specialty Erythema Keratolytic Hyperkeratosis Administration Oral Dermatology Administration Cutaneous Retinoids 030207 dermatology & venereal diseases 03 medical and health sciences Keratolytic Agents 0302 clinical medicine Stratum corneum Humans Medicine In patient Skin Skin manifestations Emollients integumentary system business.industry Ichthyosis General Medicine medicine.disease Water Loss Insensible medicine.anatomical_structure 030220 oncology & carcinogenesis Mutation Drug Therapy Combination Dermatologic Agents medicine.symptom business |
| Zdroj: | Archives of Dermatological Research. 312:237-248 |
| ISSN: | 1432-069X 0340-3696 |
| Popis: | Inherited ichthyoses are a group of etiologically heterogeneous diseases that affect the function of the skin and that are classified as syndromic and non-syndromic entities. Irrespective of the type, all these disorders are generally produced by mutations in genes involved in a variety of cellular functions in the skin. These mutations lead to disruption of the stratum corneum and impairment of the skin barrier, producing clinical features such as hyperkeratosis, skin scaling, erythema, fissures, pruritus, inflammation, and skin pain. Despite advances in the knowledge of the pathogenesis of ichthyoses, there is, to our knowledge, no definitive cure for skin manifestations, and current treatments consist of moisturizers, emollients, and keratolytic agents. In this respect, the development of new formulations based on nanotechnology could be useful to enhance their therapeutic effectiveness. In this article, we provide a comprehensive description of pharmacological treatments for cutaneous manifestations in patients with inherited ichthyosis and discuss novel approaches with therapeutic potential for this purpose. Moreover, we offer an overview of toxicity concerns related to these treatments. |
| Databáze: | OpenAIRE |
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