Effects of lansoprazole plus amoxycillin on the cure of Helicobacter pylori infection in Japanese peptic ulcer patients
| Autor: | T Sugiyama, K. Nishikawa, Mineo Kudo, Hiroshi Takeda, M. Katagiri, Masahiro Asaka, M Sukegawa, Tatsumi Koshiyama, Kaku Hokari, Hidetoshi Kagaya, Masako Kato |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Spirillaceae Lansoprazole Administration Oral Proton-pump inhibitor Penicillins Gastroenterology 2-Pyridinylmethylsulfinylbenzimidazoles Helicobacter Infections Japan Recurrence Internal medicine polycyclic compounds medicine Humans Pharmacology (medical) Stomach Ulcer Aged Antibacterial agent Helicobacter pylori Hepatology biology business.industry Stomach Amoxicillin Drug Synergism Middle Aged Anti-Ulcer Agents biology.organism_classification digestive system diseases Regimen medicine.anatomical_structure Duodenal Ulcer Concomitant Female business Omeprazole medicine.drug |
| Zdroj: | Alimentary Pharmacology & Therapeutics. 10:821-827 |
| ISSN: | 0269-2813 |
| Popis: | Aim : The effect of lansoprazole plus amoxycillin on curing Helicobacter pylori infection and peptic ulcer recurrence was evaluated. Method : The study group was composed of 68 patients with gastric ulcers and 51 with duodenal ulcers, all were H. pylori-positive. The participants were assigned at random to the lansoprazole alone group (lansoprazole 30 mg o.m. for 6 or 8 weeks) or the lansoprazole plus amoxycillin group (lansoprazole alone regimen plus amoxycillin at 500 mg q.d.s. concomitantly for the first 2 weeks). Healed patients were not given maintenance treatment with acid secretion inhibitors. The cure rate for H. pylori infection and the ulcer recurrence rate after 1 year were investigated. Result : The cure rate for H. pylori infection was 4.2% in patients receiving lansoprazole alone and 38.5% in patients receiving lansoprazole plus amoxycillin (P < 0.01) for gastric ulcers, and 0% in patients receiving lansoprazole alone and 61.9 % in patients receiving lansoprazole plus amoxycillin (P < 0.001) for duodenal ulcers. The recurrence rate was 42.3% in patients receiving lansoprazole alone and 28.6% in patients receiving lansoprazole plus amoxycillin for gastric ulcers, and 66.7% for patients receiving lansoprazole alone and 11.1 % for patients receiving lansoprazole plus amoxycillin (P < 0.001) for duodenal ulcers. None of the patients with gastric or duodenal ulcers cured of H. pylori infection had a recurrence. Conclusion : Concomitant use of lansoprazole and amoxycillin increased the curative effects on H. pylori infection. However, the cure rates with this regimen remained inadequate. |
| Databáze: | OpenAIRE |
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