Gut and Endometrial Microbiome Dysbiosis: A New Emergent Risk Factor for Endometrial Cancer
| Autor: | María José Bermejo-Pérez, Isaac Plaza-Andrades, Lidia Sánchez-Alcoholado, Maria Emilia Dominguez-Recio, Alicia González-González, Soukaina Boutriq, Rocío Lavado-Valenzuela, María Isabel Queipo-Ortuño, Emilio Alba, Aurora Laborda-Illanes, Jesús Peralta-Linero |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Uterus gut microbiome Medicine (miscellaneous) Inflammation Review endometrial microbiome Bioinformatics estrogen metabolism 03 medical and health sciences 0302 clinical medicine estrobolome Medicine Microbiome Risk factor Estrogen Metabolism business.industry Endometrial cancer dysbiosis medicine.disease Gut microbiome 030104 developmental biology medicine.anatomical_structure probiotics inflammation 030220 oncology & carcinogenesis endometrial cancer antitumour treatment medicine.symptom prebiotics business Dysbiosis |
| Zdroj: | Journal of Personalized Medicine, Vol 11, Iss 659, p 659 (2021) Journal of Personalized Medicine |
| ISSN: | 2075-4426 |
| Popis: | Endometrial cancer is one of the most common gynaecological malignancies worldwide. Histologically, two types of endometrial cancer with morphological and molecular differences and also therapeutic implications have been identified. Type I endometrial cancer has an endometrioid morphology and is estrogen-dependent, while Type II appears with non-endometrioid differentiation and follows an estrogen-unrelated pathway. Understanding the molecular biology and genetics of endometrial cancer is crucial for its prognosis and the development of novel therapies for its treatment. However, until now, scant attention has been paid to environmental components like the microbiome. Recently, due to emerging evidence that the uterus is not a sterile cavity, some studies have begun to investigate the composition of the endometrial microbiome and its role in endometrial cancer. In this review, we summarize the current state of this line of investigation, focusing on the relationship between gut and endometrial microbiome and inflammation, estrogen metabolism, and different endometrial cancer therapies. |
| Databáze: | OpenAIRE |
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