Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value
| Autor: | Jasper Koenders, Anita M. Schelen, François G. Kavelaars, Anita W. Rijneveld, Wim J. L. van Putten, Bob Löwenberg, Sanne Lugthart, Peter J. M. Valk, Annelieke Zeilemaker, Saman Abbas |
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| Přispěvatelé: | Hematology |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty NPM1 IDH1 Adolescent Immunology Biology Enasidenib medicine.disease_cause Biochemistry IDH2 Young Adult Internal medicine hemic and lymphatic diseases Prevalence medicine Humans Aged Mutation Hematology Myeloid leukemia Cell Biology Janus Kinase 2 Middle Aged Prognosis Hematologic Diseases Isocitrate Dehydrogenase Leukemia Myeloid Acute Isocitrate dehydrogenase Cancer research Female Nucleophosmin |
| Zdroj: | Blood, 116(12), 2122-2126. American Society of Hematology |
| ISSN: | 0006-4971 |
| DOI: | 10.1182/blood-2009-11-250878 |
| Popis: | Somatic mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) were recently demonstrated in acute myeloid leukemia (AML), but their prevalence and prognostic impact remain to be explored in large extensively characterized AML series, and also in various other hematologic malignancies. Here, we demonstrate in 893 newly diagnosed cases of AML mutations in the IDH1 (6%) and IDH2 (11%) genes. Moreover, we identified IDH mutations in 2 JAK2 V617F myeloproliferative neoplasias (n = 96), a single case of acute lymphoblastic leukemia (n = 96), and none in chronic myeloid leukemias (n = 81). In AML, IDH1 and IDH2 mutations are more common among AML with normal karyotype and NPM1mutant genotypes. IDH1 mutation status is an unfavorable prognostic factor as regards survival in a composite genotypic subset lacking FLT3ITD and NPM1mutant. Thus, IDH1 and IDH2 mutations are common genetic aberrations in AML, and IDH1 mutations may carry prognostic value in distinct subtypes of AML. |
| Databáze: | OpenAIRE |
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