Disparate Formulations for Machine Perfusion: A Survey of Organ Procurement Organizations' Medication Additives and Outcome Analyses
| Autor: | Jorge Ortiz, Abu Bakkar Siddique, Emily W Rady, Paul Wiederhold, Ankur P. Choubey, Naoru Koizumi |
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| Rok vydání: | 2021 |
| Předmět: |
United Network for Organ Sharing
Transplantation medicine.medical_specialty Machine perfusion Tissue and Organ Procurement business.industry Transplant recipient Graft Survival Urology Organ Preservation Kidney Kidney Transplantation Delayed Graft Function Tissue Donors United States Telephone survey Perfusion Organ procurement Treatment Outcome Medicine Humans Outcomes research business |
| Zdroj: | Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. 19(11) |
| ISSN: | 2146-8427 |
| Popis: | OBJECTIVES Machine perfusionfor kidney preservation is a common practice. There is no consensus on the best formula for perfusion solutions. We aimed to discern the additives that organ procurement organizations in the United States include in their perfusate and the impact of these additives on transplant outcomes. MATERIALS AND METHODS A telephone survey of all 58 organ procurement organizations in the United States regarding additives to their perfusion solutions was conducted. The survey data were merged with transplant recipient outcome data from the United Network for Organ Sharing database.The final analysis included perfused kidneys between January 2014 and March 2019. Logistic regressions were performed to investigate whether a particular perfusion formula was associated with delayed graft function, primary nonfunction, or early graft failure. RESULTS Additives correlated with decreased rates of graft failure were mannitol in all kidneys and kidneys of lower quality (P < .01) and penicillin/ampicillin in all kidneys (P < .05). Additives associated with increased graft failure regardless of type included verapamil in all kidneys (P < .05) and kidneys of lower quality (P < .01) and arginine with glutathione in all kidneys and low-quality kidneys alone (P < .01). CONCLUSIONS Further outcomes research and standardized guidelines for additives in machine perfusion of kidneys across all organ procurement organizations are needed. |
| Databáze: | OpenAIRE |
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