Highly Chemoselective Synthesis of Novel 6-O-phosphorylated 6-Hydroxypyridazine-3(2H)-one

Autor:	Yong Ye, Gong-Chun Li, Fengling Yang, Zhi-Yu Ju, Mei Wang, Yufen Zhao
Rok vydání:	2015
Předmět:	Organic Chemistry Condensation Hydrazine Maleic anhydride Hydrazide Biochemistry Inorganic Chemistry chemistry.chemical_compound chemistry Polymer chemistry Phosphorylation Organic chemistry Hydrate ComputingMethodologies_COMPUTERGRAPHICS
DOI:	10.6084/m9.figshare.1084381
Popis:	6-O-Phosphorylated pyridazine-3(2H)-one derivatives were conveniently prepared by a facile method. Maleic hydrazide was prepared by the condensation of maleic anhydride with 85% hydrazine hydrate. It was then chemoselectively phosphorylated at the 6-O position using the Atherton–Todd reaction. An efficient, highly chemoselective method to synthesize 6-O-phosphorylated pyridazin-3(2H)-one derivatives is provided and the approach has the merits of mild reaction conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5a8e6526420bcfb99acdddb8bce6d8 Zobrazit plný text záznamu