Biphasic interaction of gamma-globulin with copper cations
| Autor: | S. B. Cheknev, E. E. Babaeva, M. S. Zharkova |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Absorption spectroscopy
Chemistry Protein Conformation Inorganic chemistry chemistry.chemical_element General Medicine Copper Blood proteins General Biochemistry Genetics and Molecular Biology Metal Spectrophotometry visual_art Intramolecular force Cations visual_art.visual_art_medium Molecule Humans gamma-Globulins Binding site Saturation (chemistry) |
| Zdroj: | Bulletin of experimental biology and medicine. 139(5) |
| ISSN: | 0007-4888 |
| Popis: | Interactions of human serum gamma-globulin with copper cations in solution were studied by differential ultraviolet spectrophotometry. Copper in supraphysiological concentrations increases optical density of protein solution, reflecting the effect of gamma-globulin saturation with metal. In physiological and lower concentrations of copper cations we observed hypochromia in the protein absorption spectrum. Conformational changes in g-globulin molecule during interactions with copper by the surface and intramolecular binding sites and possible role of bivalent metal cations in the maintenance of certain conformations of immunoactive serum proteins are discussed. |
| Databáze: | OpenAIRE |
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