Glomerular filtration rate in Indian non-insulin-dependent diabetics at various stages of albuminuria
| Autor: | Regi Oommnen, Prasad Mathews, Lily John |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Kidney Glomerulus Radioimmunoassay India Renal function urologic and male genital diseases Endocrinology Diabetes mellitus Internal medicine Internal Medicine medicine Albuminuria Humans Proteinuria business.industry Non insulin dependent diabetes mellitus General Medicine Middle Aged medicine.disease female genital diseases and pregnancy complications Diabetes Mellitus Type 2 Hypertension Female Microalbuminuria medicine.symptom business Glomerular Filtration Rate |
| Zdroj: | Diabetes Research and Clinical Practice. 23:121-125 |
| ISSN: | 0168-8227 |
| DOI: | 10.1016/0168-8227(94)90019-1 |
| Popis: | Sixty-seven non-insulin-dependent diabetic subjects were selected to estimate the glomerular filtration rate (GFR). All patients had satisfactory glycaemic control (HbA19.5%). GFR was determined using Technetium 99m DTPA by the method devised by Gates. Thirty-eight subjects had normal albumin excretion (UAE20 micrograms/min), 15 had UAE in the microalbuminuric range (20-100 micrograms/min), and the rest were macroalbuminuric (200 micrograms/min). GFR was lower in the normoalbuminuric patients as compared to the controls, but the decrease was not significant (71.5 (21.4) vs. 98.3 (16.1) ml/min per 1.73 m2. GFR was significantly decreased in both micro and macroalbuminuric groups (64.0 (24.5) and 53.8 (27.3) ml/min per 1.73 m2, respectively) (P0.05). No appreciable change in GFR was observed in normoalbuminuric patients with increasing duration of diabetes, however, there was a steady decline in GFR with time in both micro- and macroalbuminuric patients. Hypertension was present in 79%, 47% and 16% of macro-, micro- and normoalbuminuric patients, respectively. GFR was significantly lower in hypertensive diabetic patients compared to normotensives (52.3 vs. 76.1 ml/min per 1.73 m2) (P0.01), while this difference was not significant in the micro- and macroalbuminuric groups. We conclude from our study that the stage of hyperfiltration could not be detected in non-insulin-dependent diabetes and that hypertension has a significant influence on the rate of decline of GFR. |
| Databáze: | OpenAIRE |
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