Endogenous immunoreactive ouabain-like and digoxin-like factors in reduced renal mass hypertensive rats
| Autor: | Motoya Nakagawa, Nobuyuki Ura, Jun-ichi Kaide, Hideaki Yoshida, Kazuaki Shimamoto, Tamaki Takada |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Digoxin Hypertension Renal Physiology Urinary system medicine.medical_treatment Urine Kidney Ouabain Excretion Rats Sprague-Dawley Biological Factors Internal medicine Internal Medicine medicine Animals Saline business.industry Sodium Organ Size Saponins Rats Cardenolides Blood pressure Endocrinology medicine.anatomical_structure Renal sodium excretion Sodium-Potassium-Exchanging ATPase Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Hypertension research : official journal of the Japanese Society of Hypertension. 21(3) |
| ISSN: | 0916-9636 |
| Popis: | We evaluated the urinary excretion of immunoreactive endogenous ouabain-like factor (OLF) and digoxin-like factor (DLF) to investigate their pathophysiological roles in sodium metabolism and blood pressure in 5/6-reduced renal mass rats, a model of volume-expanded hypertension. About five-sixths of the kidney mass (5/6 RRM, n = 9) was removed from male Sprague-Dawley rats, or the rats were sham operated (control, n = 10). Both groups were fed regular diets with tap water for 1 wk as a control period, followed by 1% saline solution for 4 wk. Systolic blood pressure (SBP), urine volume (UV), urinary sodium excretion (UNaV), DLF, and OLF were measured on the last 2 d of every week throughout the experimental period. SBP and UNaV were significantly higher in 5/6 RRM rats than in control rats. Urinary DLF significantly increased, reaching peak value in the first week, while OLF increased continuously, reaching peak value in the fourth week. In the first week, there were a significant positive correlations between the change in DLF and the changes in UNaV and SBP. However, the change in OLF was not correlated with changes in either UNaV or SBP. Both SBP and UNaV showed a significant positive correlation with OLF (p |
| Databáze: | OpenAIRE |
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