Understanding Growth Failure in Costello Syndrome: Increased Resting Energy Expenditure

Autor:	Daniela Giorgio, Valentina Giorgio, Lucilla Martini, A. Rossodivita, Roberta Onesimo, Marco Tartaglia, Chiara Leoni, Giuseppe Zampino, Antonella Diamanti
Rok vydání:	2015
Předmět:	0301 basic medicine Adult Male Pediatrics medicine.medical_specialty Adolescent Rest Energy metabolism Growth hormone Proto-Oncogene Mas 03 medical and health sciences Young Adult 0302 clinical medicine Costello syndrome Internal medicine Medicine Humans Resting energy expenditure HRAS Young adult Child business.industry Costello Syndrome Perinatology and Child Health medicine.disease Failure to Thrive 030104 developmental biology Endocrinology Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA Case-Control Studies Child Preschool Failure to thrive Pediatrics Perinatology and Child Health Female medicine.symptom business Energy Metabolism 030217 neurology & neurosurgery
Zdroj:	The Journal of pediatrics. 170
ISSN:	1097-6833
Popis:	Costello syndrome is a rare multisystem disorder caused by mutations in the proto-oncogene HRAS. Failure to thrive is one of its cardinal clinical features. This study documents that individuals with Costello syndrome have increased resting energy expenditure. We speculate this could be one of the potential mechanisms causing failure to thrive.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de504582e9148b7eee186b84b7d25fbb https://pubmed.ncbi.nlm.nih.gov/26778095 Zobrazit plný text záznamu Full Text from ScienceDirect