Desquamative interstitial pneumonia following long-term nitrofurantoin therapy
| Autor: | William E. Ruth, Roger C. Bone, Daniel J. Stechschulte, Gerald R. Kerby, John E. Wolfe, Maura Welch, Richard E. Sobonya |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Pulmonary Fibrosis Fluorescent Antibody Technique Immunoglobulin E Desquamative interstitial pneumonia Basilar Rales Biopsy medicine Humans Aged Lung biology medicine.diagnostic_test business.industry Lymphoblast Interstitial lung disease Complement C3 General Medicine medicine.disease respiratory tract diseases Pulmonary Alveoli Dyspnea medicine.anatomical_structure Nitrofurantoin Urinary Tract Infections biology.protein business medicine.drug |
| Zdroj: | The American Journal of Medicine. 60:697-701 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/0002-9343(76)90505-2 |
| Popis: | Two patients with diffuse interstitial lung disease after long-term nitrofurantoin therapy were characterized clinically by exertional dyspnea and basilar rales, roentgenographically by diffuse interstitial infiltrate and physiologically by a restrictive lung defect. Pathologically, light microscopy revealed desquamative interstitial pneumonia. In one patient electron microscopy was characteristic of desquamative interstitial pneumonia. Immunofluorescent studies of one biopsy specimen showed specific fluorescence of interstitial cells with immunoglobulin E and third component of complement. In in vitro studies, nitrofurantoin therapy failed to induce lymphoblast transformation or histamine release. Treatment consisted of discontinuing the administration of nitrofurantoin and adding corticosteroids. Both patients felt better and showed clinical improvement. Our findings suggest that in some cases desquamative interstitial pneumonia may be drug related. |
| Databáze: | OpenAIRE |
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