The physics of protein self-assembly
| Autor: | Emanuela Zaccarelli, Patrick Charbonneau, Neer Asherie, Jennifer J. McManus |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Polymers and Plastics
Globular protein FOS: Physical sciences 02 engineering and technology Condensed Matter - Soft Condensed Matter 010402 general chemistry 01 natural sciences Protein–protein interaction Virus capsids Colloid and Surface Chemistry Amyloids Physics - Biological Physics Soft matter Physical and Theoretical Chemistry chemistry.chemical_classification Protein Biomolecules (q-bio.BM) Surfaces and Interfaces Self-assembly 021001 nanoscience & nanotechnology Amyloid fibril 0104 chemical sciences 3. Good health Quantitative Biology - Biomolecules chemistry Biological Physics (physics.bio-ph) FOS: Biological sciences Biophysics Soft Condensed Matter (cond-mat.soft) Patchy colloids 0210 nano-technology Crystallization |
| Zdroj: | Current opinion in colloid & interface science 22 (2016): 73–79. doi:10.1016/j.cocis.2016.02.011 info:cnr-pdr/source/autori:Jennifer J. McManus; Patrick Charbonneau; Emanuela Zaccarelli; Neer Asherie/titolo:The physics of protein self-assembly/doi:10.1016%2Fj.cocis.2016.02.011/rivista:Current opinion in colloid & interface science/anno:2016/pagina_da:73/pagina_a:79/intervallo_pagine:73–79/volume:22 |
| DOI: | 10.1016/j.cocis.2016.02.011 |
| Popis: | Understanding protein self-assembly is important for many biological and industrial processes. Proteins can self-assemble into crystals, filaments, gels, and other amorphous aggregates. The final forms include virus capsids and condensed phases associated with diseases, such as amyloid fibrils. Although seemingly different, these assemblies all originate from fundamental protein interactions and are driven by similar thermodynamic and kinetic factors. Here we review recent advances in understanding protein self-assembly through a soft condensed matter perspective with an emphasis on three specific systems: globular proteins, viruses and amyloid fibers. We conclude with a discussion of unanswered questions in the field. 18 pages, 4 figures, CECAM Workshop |
| Databáze: | OpenAIRE |
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