Fucoidans from the phaeophyta Scytosiphon lomentaria: Chemical analysis and antiviral activity of the galactofucan component
| Autor: | Carlos A. Stortz, María L. Flores, Elsa B. Damonte, Nora M.A. Ponce, Mónica B. Becerra, Diego A. Navarro, Osvaldo León Córdoba, Carlos A. Pujol |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Herpesvirus 2
Human Mannose Fractionation Herpesvirus 1 Human Microbial Sensitivity Tests Xylose 010402 general chemistry Phaeophyta 01 natural sciences Biochemistry Antiviral Agents Fucose Analytical Chemistry Scytosiphon lomentaria chemistry.chemical_compound Sulfation Polysaccharides Carbohydrate Conformation Monosaccharide chemistry.chemical_classification biology 010405 organic chemistry Organic Chemistry Galactose General Medicine biology.organism_classification 0104 chemical sciences chemistry |
| Zdroj: | Carbohydrate research. 478 |
| ISSN: | 1873-426X |
| Popis: | The brown seaweed Scytosiphon lomentaria produces moderate amounts of fucoidans. By cetrimide fractionation, typical heavily sulfated galactofucans are obtained, with no major signs of chemical heterogeneity, together with fractions with higher proportions of xylose, mannose and uronic acids. Anyway, fucose is the most important monosaccharide in most of the subfractions of the subsequent extracts. The fucan moieties appear to be mostly as 3-linked α-l-fucopyranosyl units, with several patterns of sulfate and branching. Galactose is mostly 6-linked, whereas mannose appears to be 2-linked, and xylose appears mostly as terminal stubs. Small amounts of 2-O-acetylated fucose units appear. A high and selective antiviral activity against HSV-1 and HSV-2 was determined for the galactofucan fractions whereas the uronofucoidans were inactive. |
| Databáze: | OpenAIRE |
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