Prospective cohort study of children exposed to hepatitis C virus through a pregnancy screening program
| Autor: | Kara Chew, Maria Inês Gonzalez Solari, Ana Regina Lima Ramos, Raquel Borges Pinto, Leidy Tovar Padua, Juliana Ferraz de Correa, Breno Santos, Emma Swayze, Karin Nielsen-Saines, Mara Liane Rieck Silveira, Marineide Gonçalves de Melo, Ivete Cristina Teixeira Canti, Maristela Fiorini, Ivana Varella, Mary Catherine Cambou |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Longitudinal study medicine.medical_specialty Hepatitis C virus MTCT HCV Viremia Hepacivirus Infectious and parasitic diseases RC109-216 medicine.disease_cause Article Seroepidemiologic Studies Pregnancy Internal medicine Medicine Seroprevalence Humans Longitudinal Studies Prospective Studies Pregnancy Complications Infectious Prospective cohort study Child business.industry Transmission (medicine) HCV screening Infant virus diseases General Medicine medicine.disease Hepatitis C digestive system diseases Infectious Diseases Population study Female business Infants Brazil |
| Zdroj: | International Journal of Infectious Diseases, Vol 110, Iss, Pp 62-68 (2021) International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases |
| ISSN: | 1201-9712 |
| Popis: | Objectives: Porto Alegre, in south Brazil, has one of the highest hepatitis C virus (HCV) infection rates in the country (84.4 cases/100 000 in 2018). Prenatal screening of HCV, however, has not been routinely offered. Methods: A longitudinal study of pregnant women with HCV and their infants was conducted between January 2014 and December 2018. Screening for HCV antibodies was offered to all women delivering at the study tertiary institution. HCV RT-PCR was performed if the woman was seropositive. Infants were followed prospectively. Results: Among 18 953 pregnant women delivering infants during the study period, 17 810 were screened for HCV antibodies (93.9%) with 130 positive results (HCV seroprevalence 0.7%). HCV-RNA was detectable in 57/117 cases (48.7%). HCV viremia was associated with the use of injectable drugs (P = 0.03), inhaled/crack drug use (P = 0.02), having an HCV-seropositive partner, and ≥3 lifetime sexual partners (P < 0.01). Genotype 1 was most prevalent (68%) during pregnancy. Among 43 children with follow-up, six (13%) were HCV-infected (transmission rate 13.9%); 50% were infected with genotype 3. Two infants (33%) cleared their infection; the mothers had genetic polymorphisms associated with clearance. Conclusion: HCV vertical transmission was high in the study population, with HCV infection during pregnancy being vastly underdiagnosed. Public health efforts must focus on this vulnerable population for disease prevention and early treatment. |
| Databáze: | OpenAIRE |
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