Triaging women with human papillomavirus infection and normal cytology or low‐grade dyskaryosis: evidence from 10‐year follow up of the ARTISTIC trial cohort
| Autor: | Clare Gilham, Julian Peto, A Sargent |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Dyskaryosis Uterine Cervical Neoplasms Cervical intraepithelial neoplasia Young Adult 03 medical and health sciences Age Distribution 0302 clinical medicine Risk Factors Cytology medicine Humans Stage (cooking) Early Detection of Cancer Aged Colposcopy Human papillomavirus 16 030219 obstetrics & reproductive medicine Cervical screening Human papillomavirus 18 medicine.diagnostic_test Obstetrics business.industry Papillomavirus Infections HPV infection Obstetrics and Gynecology Middle Aged Uterine Cervical Dysplasia medicine.disease female genital diseases and pregnancy complications England Cohort Female Mini Commentary Triage business Follow-Up Studies |
| Zdroj: | Bjog |
| ISSN: | 1471-0528 1470-0328 |
| DOI: | 10.1111/1471-0528.15957 |
| Popis: | Objectives To estimate long-term cervical intraepithelial neoplasia grade 3 (CIN3) risks associated with different triage strategies for human papillomavirus positive (HPV+) women with a view to reducing unnecessary referrals. Design The ARTISTIC trial cohort was recruited in Manchester in 2001-03 and was followed up for CIN3 and cancer notification through national registration until December 2015. Results The 10-year cumulative risk of CIN3+ was much higher for women with HPV16/18 infection (19.4%, 95% CI 15.8-23.8% with borderline/low-grade cytology and 10.7%, 95% CI 8.3-13.9% with normal cytology) than for those with other HPV types (7.3%, 95% CI 5.4-9.7% with borderline/low-grade cytology and 3.2%, 95% CI 2.2-4.5% with normal cytology). Among the 379 women with normal to low-grade cytology and new HPV infection, the 10-year cumulative CIN3+ risk was 2.9% (95% CI 1.6-5.2%). Conclusions The CIN3 risk is confined to women with persistent type-specific HPV so partial genotyping test assays identifying HPV16/18 as a minimum are essential for efficient risk stratification. Immediate referral to colposcopy for HPV+ women with borderline or low-grade cytology and referral after a year if still HPV+ with normal cytology may be unnecessary. Low-grade lesions can safely be retested to identify those with persistent HPV. Recall intervals of 1 year for HPV16/18 and 2 years for other high-risk HPVs are justified for women with normal cytology and might also be considered for women with borderline/low-grade cytology. The minimal risk of invasive cancer that has progressed beyond stage 1A must be weighed against the advantages for patients and the NHS of reducing the number of referrals to colposcopy. Tweetable abstract Cervical screening would be better for women and cheaper for the NHS if women with HPV and normal to low-grade cytology were retested after a year or two when many infections will have cleared. |
| Databáze: | OpenAIRE |
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