Autoradiographic analysis of serotonin 5-HT1A receptor binding in the human brain postmortem: effects of age and alcohol
| Autor: | Malka Israeli, Ruth Gross-Isseroff, Anat Biegon, Kathryn A. Dillon |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Aging Adolescent Tetrahydronaphthalenes Hippocampal formation Tritium Hippocampus Internal medicine medicine Humans heterocyclic compounds Receptor Molecular Biology 5-HT receptor Aged Cerebral Cortex 8-Hydroxy-2-(di-n-propylamino)tetralin Ethanol Chemistry musculoskeletal neural and ocular physiology General Neuroscience Brain Human brain Middle Aged Ligand (biochemistry) Suicide medicine.anatomical_structure Endocrinology nervous system Organ Specificity Postmortem Changes Receptors Serotonin 5-HT1A receptor Autoradiography Raphe Nuclei Female Neurology (clinical) Serotonin Raphe nuclei Neuroscience Developmental Biology |
| Zdroj: | Brain research. 554(1-2) |
| ISSN: | 0006-8993 |
| Popis: | Quantitative autoradiographic analysis of serotonin 5-HT1A receptors in the human brain, using [3H]8-OH-DPAT as a ligand, reveals region-specific decreases in receptor labeling with age in several cortical and hippocampal regions and in the raphe nuclei. This is due to a change in receptor density (Bmax) with no apparent change in affinity (Kd) as affirmed by saturation binding analysis on representative cortical regions. The presence of alcohol is associated with decreased binding in several cortical gyri. Suicide, gender and postmortem delay had no effect on 8-OH-DPAT binding. |
| Databáze: | OpenAIRE |
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