Littoral Cell Angioma of the Spleen: An Additional Report of Four Cases with Emphasis on the Association with Visceral Organ Cancers
| Autor: | Michele Bisceglia, Joshua Z. Sickel, Felice Giangaspero, Michal Michal, Mostafa' Amini, Vito Gomes |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Spleen angioma 030218 nuclear medicine & medical imaging Neoplasms Multiple Primary Meningioma Angioma 03 medical and health sciences 0302 clinical medicine medicine Humans visceral malignancies littoral cell Histiocyte Aged Ovarian Neoplasms Brain Neoplasms Rectal Neoplasms business.industry Splenic Neoplasms General Medicine Middle Aged medicine.disease Kidney Neoplasms Lymphoma Pancreatic Neoplasms medicine.anatomical_structure Oncology Littoral cell angioma 030220 oncology & carcinogenesis Colonic Neoplasms vascular tumor Red pulp Adenocarcinoma Female spleen Hemangioma business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 2038-2529 0300-8916 |
| DOI: | 10.1177/030089169808400516 |
| Popis: | Aims and background Littoral cell angioma (LCA) is an uncommon vascular tumor of the spleen recently described and interpreted as the tumoral counterpart of the normally present littoral cells lining the splenic sinus channels of red pulp. The diagnosis of LCA is suggested by a quite characteristic morphology and confirmed by the demonstration of a hybrid endothelial/histiocytic phenotype. Methods Four original and previously unreported cases of LCA are presented. All four splenic vascular tumors were investigated by light microscopy and immunohistochemistry for endothelial and histiocytic markers. Results All four cases were associated with visceral epithelial malignancies (colorectal adenocarcinoma in two cases, renal and pancreatic adenocarcinoma in one case each). One case was also associated with an intracranial tentorial meningioma. Conclusions We consider our findings as a novelty and signal the possible existence of a clinical syndrome. Five of a total of 21 previously reported cases in the literature were also described as being associated with other cancers (non-Hodgkin's lymphoma in two cases, two not further specified tumors of the liver and brain, an epithelial ovarian cancer, and a non-small cell lung cancer in one case each). Close follow-up and careful investigation in search of a second visceral neoplasm are strongly recommended in cases of LCA, but further clinical observations and more in-depth genetic and molecular studies are needed before any valid conclusions can be drawn. |
| Databáze: | OpenAIRE |
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