Role of the renin-angiotensin system on abdominal aortic aneurysms

Autor: Nikolaos Stergiopulos, Rodrigo A. Fraga-Silva, Sonaz Malekzadeh, François Mach, Fabrizio Montecucco, Bram Trachet
Rok vydání: 2013
Předmět:
medicine.medical_specialty
Angiotensin II Type 1 Receptor Blockers/therapeutic use
Clinical Biochemistry
Angiotensin-Converting Enzyme Inhibitors
macromolecular substances
030204 cardiovascular system & hematology
Bioinformatics
Biochemistry
Receptor
Angiotensin
Type 1
Renin-Angiotensin System
03 medical and health sciences
Aortic aneurysm
Mice
0302 clinical medicine
Degenerative disease
angiotensin-converting enzyme
Internal medicine
Renin–angiotensin system
Medicine
Animals
Humans
cardiovascular diseases
030304 developmental biology
ddc:616
Renin-Angiotensin System/drug effects/physiology
0303 health sciences
Angiotensin II receptor type 1
biology
Receptor
Angiotensin
Type 1/physiology
business.industry
Aortic Aneurysm
Abdominal/drug therapy/etiology
Angiotensin-converting enzyme
General Medicine
medicine.disease
Angiotensin II
Pathophysiology
Abdominal aortic aneurysm
3. Good health
Angiotensin-Converting Enzyme Inhibitors/therapeutic use
Disease Models
Animal
Endocrinology
biology.protein
cardiovascular system
business
Angiotensin II Type 1 Receptor Blockers
Aortic Aneurysm
Abdominal
Forecasting
Zdroj: European Journal of Clinical Investigation
European journal of clinical investigation
European Journal of Clinical Investigation, Vol. 43, No 12 (2013) pp. 1328-1338
European Journal of Clinical Investigation; Vol 43
ISSN: 0014-2972
DOI: 10.1111/eci.12173
Popis: Background: Abdominal aortic aneurysm (AAA) is a complex degenerative disease which leads to morbidity and mortality in a large portion of the elderly population. Current treatment options for AAA are quite limited as there is no proven indication for pharmacological therapy and surgery is recommended for AAA larger than 5·5 cm in luminal diameter. Thus there is a great need to elucidate the underlying pathophysiological cellular and molecular mechanisms to develop effective therapies. In this narrative review we will discuss recent findings concerning some potential molecular and clinical aspects of the renin angiotensin system (RAS) in AAA pathophysiology. Materials and methods: This narrative review is based on the material found on MEDLINE and PubMed up to April 2013. We looked for the terms 'angiotensin AT1 receptor ACE inhibitors' in combination with 'abdominal aortic aneurysm pathophysiology pathways'. Results: Several basic research and clinical studies have recently investigated the role of the RAS in AAA. In particular the subcutaneous infusion of Angiotensin II has been shown to induce AAA in Apo56 knockout mice. On the other hand the pharmacological treatments targeting this system have been shown as beneficial in AAA patients. Conclusions: Emerging evidence suggests that RAS may act as a molecular and therapeutic target for treating AAA. However several issues on the role of RAS and the protective activities of angiotensin converting enzyme (ACE) inhibitors and Angiotensin 1 receptors blockers against AAA require further clarifications. © 2013 Stichting European Society for Clinical Investigation Journal Foundation.
Databáze: OpenAIRE
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