Structured Genome-Wide Association Studies with Bayesian Hierarchical Variable Selection
| Autor: | Hongtu Zhu, Yize Zhao, Fei Zou, Zhaohua Lu, Rebecca C. Knickmeyer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Genetic Markers
Bayesian probability Inference Genome-wide association study Feature selection Neuroimaging Biology Investigations Machine learning computer.software_genre 01 natural sciences Polymorphism Single Nucleotide SNP-set Set (abstract data type) 010104 statistics & probability 03 medical and health sciences symbols.namesake Alzheimer Disease Genetics Humans Computer Simulation 0101 mathematics Selection (genetic algorithm) 030304 developmental biology Genetic association Bayesian variable selection 0303 health sciences Models Genetic business.industry Markov chain Monte Carlo Bayes Theorem Markov Chains Phenotype genome-wide association studies symbols imaging genetics Artificial intelligence business computer Statistical Genetics and Genomics Algorithms Genome-Wide Association Study |
| Zdroj: | Genetics |
| ISSN: | 1943-2631 0016-6731 |
| Popis: | It becomes increasingly important in using genome-wide association studies (GWAS) to select important genetic information associated with qualitative or quantitative traits. Currently, the discovery of biological association among SNPs motivates various strategies to construct SNP-sets along the genome and to incorporate such set information into selection procedure for a higher selection power, while facilitating more biologically meaningful results. The aim of this paper is to propose a novel Bayesian framework for hierarchical variable selection at both SNP-set (group) level and SNP (within group) level. We overcome a key limitation of existing posterior updating scheme in most Bayesian variable selection methods by proposing a novel sampling scheme to explicitly accommodate the ultrahigh-dimensionality of genetic data. Specifically, by constructing an auxiliary variable selection model under SNP-set level, the new procedure utilizes the posterior samples of the auxiliary model to subsequently guide the posterior inference for the targeted hierarchical selection model. We apply the proposed method to a variety of simulation studies and show that our method is computationally efficient and achieves substantially better performance than competing approaches in both SNP-set and SNP selection. Applying the method to the Alzheimers Disease Neuroimaging Initiative (ADNI) data, we identify biologically meaningful genetic factors under several neuroimaging volumetric phenotypes. Our method is general and readily to be applied to a wide range of biomedical studies. |
| Databáze: | OpenAIRE |
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