Accumulation of Symmetric Dimethylarginine in Hepatorenal Syndrome
| Autor: | Paloma Lluch, María Dolores Mauricio, Pascual Medina, Gloria Segarra, José M. Rodrigo, Miguel A. Serra, Juan A. del Olmo, José M. Vila |
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| Rok vydání: | 2006 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Hepatorenal Syndrome Cirrhosis Arginine Kidney Nitric Oxide General Biochemistry Genetics and Molecular Biology Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Hepatorenal syndrome Internal medicine medicine Humans Renal Insufficiency Creatinine business.industry Kidney metabolism Middle Aged medicine.disease Fibrosis 030104 developmental biology Endocrinology medicine.anatomical_structure Liver chemistry Case-Control Studies 030220 oncology & carcinogenesis medicine.symptom Asymmetric dimethylarginine business Vasoconstriction |
| Zdroj: | Experimental Biology and Medicine. 231:70-75 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.1177/153537020623100108 |
| Popis: | In patients with cirrhosis, nitric oxide (NO), asymmetric dimethylarginine (ADMA), and possibly symmetric dimethylarginine (SDMA) have been linked to the severity of the disease. We investigated whether plasma levels of dimethylarginines and NO are elevated in patients with hepatorenal syndrome (HRS), compared with patients with cirrhosis without renal failure (no-HRS). Plasma levels of NO, ADMA, SDMA, and l-arginine were measured in 11 patients with HRS, seven patients with no-HRS, and six healthy volunteers. SDMA concentration in HRS was higher than in no-HRS and healthy subjects (1.47 ± 0.25 vs. 0.38 ± 0.06 and 0.29 ± 0.04 μM, respectively; P < 0.05). ADMA and NOx concentrations were higher in HRS and no-HRS patients than in healthy subjects (ADMA, 1.20 ± 0.26, 1.11 ± 0.1, and 0.53 ± 0.06 μM, respectively; P < 0.05; NOx, 94 ± 9.1, 95.5 ± 9.54, and 37.67 ± 4.62 μM, respectively; P < 0.05). In patients with HRS there was a positive correlation between serum creatinine and plasma SDMA (r2 = 0.765, P < 0.001) but not between serum creatinine and ADMA or NOx. The results suggest that renal dysfunction is a main determinant of elevated SDMA concentration in HRS. Accumulation of ADMA as a result of impaired hepatic removal may be the causative factor initiating renal vasoconstriction and SDMA retention in the kidney. |
| Databáze: | OpenAIRE |
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