Leptin in Depressive Episodes: Is There a Difference between Unipolar and Bipolar Depression?

Autor: Bárbara Coiro Spessato, Diogo R. Lara, Gisele Cordas, Eduardo M Schuch, Manuella P. Kaster, Luiz Valmor Portela, Luciano Dias de Mattos Souza, Ricardo Tavares Pinheiro, Karen Jansen, Ricardo Azevedo da Silva, Jerônimo Costa Branco, Gabriele Ghisleni, Luciana de Avila Quevedo, Jean Pierre Oses, Marta Gazal
Rok vydání: 2015
Předmět:
Zdroj: Neuroendocrinology. 101:82-86
ISSN: 1423-0194
0028-3835
Popis: Objective: The present study investigated whether peripheral leptin levels are associated with current depressive episodes in a cross-sectional study nested within a population-based study. Methods: The Mini-International Neuropsychiatric Interview (MINI) 5.0 was used to assess the presence of current depressive episodes. The sample was composed of 206 subjects (103 controls and 103 subjects with a current depressive episode) paired by gender, BMI and age. Medication use and lifestyle characteristics were self-reported. Results: Serum leptin levels were lower in currently depressive subjects (10.9 ± 12.0 ng/ml) than in the control group (20.3 ± 24.0 ng/ml; p = 0.023). According to the clinical diagnosis, individuals with bipolar depression present lower leptin levels (8.4 ± 8.1 ng/ml) than those with unipolar depression (12.0 ± 13.4 ng/ml) and the control group (20.3 ± 24.0 ng/ml; p = 0.031). In addition, ANCOVA showed that leptin is an independent factor associated with current depressive episodes (p = 0.018). Conclusion: A decreased leptin level might be a useful peripheral marker associated with depressive episodes in the context of bipolar disorder.
Databáze: OpenAIRE