Mannitol-Enhanced Delivery of Stem Cells and Their Growth Factors Across the Blood–Brain Barrier
| Autor: | Cesar V. Borlongan, Paul R. Sanberg, Chiara Gonzales-Portillo, Gabriel S. Gonzales-Portillo, Theo Diamandis, Cyndy D. Sanberg, Max Franzblau, Meaghan Staples |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_treatment
Biomedical Engineering lcsh:Medicine Cord Blood Stem Cell Transplantation Blood–brain barrier Bioinformatics Article Cerebral palsy Neurotrophic factors Ischemia medicine Animals Humans Mannitol Nerve Growth Factors Stroke Transplantation business.industry Stem Cells lcsh:R Cell Biology Stem-cell therapy medicine.disease Clinical trial medicine.anatomical_structure Blood-Brain Barrier Anesthesia Stem cell business Stem Cell Transplantation |
| Zdroj: | Cell Transplantation, Vol 23 (2014) |
| Popis: | Ischemic brain injury in adults and neonates is a significant clinical problem with limited therapeutic interventions. Currently, clinicians have only tPA available for stroke treatment and hypothermia for cerebral palsy. Owing to the lack of treatment options, there is a need for novel treatments such as stem cell therapy. Various stem cells including cells from embryo, fetus, perinatal, and adult tissues have proved effective in preclinical and small clinical trials. However, a limiting factor in the success of these treatments is the delivery of the cells and their by-products (neurotrophic factors) into the injured brain. We have demonstrated that mannitol, a drug with the potential to transiently open the blood–brain barrier and facilitate the entry of stem cells and trophic factors, as a solution to the delivery problem. The combination of stem cell therapy and mannitol may improve therapeutic outcomes in adult stroke and neonatal cerebral palsy. |
| Databáze: | OpenAIRE |
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