Using assessment of higher brain functions of children with GJB2-associated deafness and cochlear implants as a procedure to evaluate language development
| Autor: | Kunihiro Fukushima, Shoichiro Fukuda, Kazunori Nishizaki, Akihiro Kawasaki, Yuko Kataoka |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Deafness Neuropsychological Tests Audiology Verbal learning Language Development Connexins Raven's Progressive Matrices Audiometry Language assessment learninng disability Cochlear implant Aphasia otorhinolaryngologic diseases medicine Humans Genetic Testing Child higher brain function business.industry Cognitive disorder cochlear implant Dyslexia non-syndromic hearing loss General Medicine medicine.disease GJB2 Connexin 26 Language development Cochlear Implants Otorhinolaryngology Mutation Pediatrics Perinatology and Child Health Speech Perception medicine.symptom business |
| Zdroj: | International Journal of Pediatric Otorhinolaryngology. 70:1343-1349 |
| ISSN: | 0165-5876 |
| DOI: | 10.1016/j.ijporl.2006.01.010 |
| Popis: | Objective: While investigators have reported that patients with GJB2-associated deafness and cochlear implants have preferable language development, the mechanisms of this phenomenon remains unknown. The goat of the present study was to assess higher brain functions of patients with GJB2-retated and GJB2-unrelated deafness as a method of evaluating language development. Methods: Eight children with cochlear implants were subjected to genetic testing for GJB2 and underwent the Raven colored progressive matrices test, Rey's auditory verbal learning test, Rey's complex figure test, the standardized Language test for aphasia, the picture vocabulary test, and the standardized comprehension test for abstract words. Results:Three children were diagnosed with GJB2-related deafness, and five children were diagnosed with GJB2-unrelated deafness. All three GJB2-related cases demonstrated normal range higher brain functions and fair language development. By contrast, one GJB2-unrelated case showed a semantic disorder, another demonstrated a visual cognitive disorder with dyslexia, and another had attention deficit-hyperactivity disorder. Conclusions:Children with GJB2-unrelated deafness showed a high frequency of heterogeneous disorders that can affect proper language development. This difference between children with GJB2-retated and GJB2-unrelated deafness may account for the improved language development in children with GJB2-related deafness and cochlear implants. Further, genetic diagnosis of the non-syndromic hearing toss represents a useful tool for the preoperative prediction of outcomes following a cochlear implant procedure. |
| Databáze: | OpenAIRE |
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