Intrahippocampal GMP administration improves inhibitory avoidance performance through GABAergic and glutamatergic mechanisms in rats
| Autor: | Maribel Antonello Rubin, R.L. Boemo, de Mello Cf, Alexandre Jurach, G.R. Zanolla, Diogo O. Souza |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Baclofen Microinjections Agonist-antagonist Hippocampus Receptors N-Methyl-D-Aspartate Functional Laterality chemistry.chemical_compound Internal medicine medicine Avoidance Learning Reaction Time Animals Rats Wistar Neurotransmitter Cyclic GMP GABA Agonists gamma-Aminobutyric Acid Muscimol General Neuroscience Glutamate receptor Rats Dizocilpine Endocrinology nervous system chemistry NMDA receptor GABAergic Dizocilpine Maleate medicine.drug |
| Zdroj: | Neuroreport. 8(17) |
| ISSN: | 0959-4965 |
| Popis: | Guanidino compounds play specific physiological and pathological roles in the central nervous system. We investigated the effect of an intrahippocampal infusion of GMP (a guanidino compound) administered immediately post-training on the inhibitory avoidance learning paradigm in rats. Bilateral intrahippocampal micro-injection of GMP (0-30 nmol) caused a dose-dependent increase in test step-down latencies which was completely reversed by intrahippocampal co-administration of muscimol or baclofen (GABA agonists) or preadministration (15 min pre-training, i.p.) of MK-801 (an NMDA antagonist). These results provide evidence for a participation of GABA and NMDA receptors in the GMP-induced increase in the test step-down latencies. |
| Databáze: | OpenAIRE |
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