CRTH2 expression on T cells in asthma
| Autor: | Ian D. Pavord, Caroline E. Day, K Mutalithas, Christopher E. Brightling, Andrew J. Wardlaw, C. Guillen |
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| Rok vydání: | 2010 |
| Předmět: |
Male
CRTH2 Translational Studies Allergy Receptors Prostaglandin chemistry.chemical_compound 0302 clinical medicine Interferon Adrenal Cortex Hormones T-Lymphocyte Subsets Immunology and Allergy Medicine Anti-Asthmatic Agents Receptors Immunologic 0303 health sciences education.field_of_study Interleukin-13 medicine.diagnostic_test Prostaglandin D2 Interleukin respiratory system Middle Aged 3. Good health medicine.anatomical_structure Interleukin 13 Female Bronchoalveolar Lavage Fluid medicine.drug Adult medicine.medical_specialty T cell Immunology Population 03 medical and health sciences Young Adult Th2 Cells Internal medicine Bronchoscopy Humans Lymphocyte Count education Interleukin 4 030304 developmental biology Aged business.industry asthma lung T cell Bronchoalveolar lavage Endocrinology chemistry Interleukin-4 business 030215 immunology |
| Zdroj: | Clinical and Experimental Immunology |
| ISSN: | 1365-2249 |
| Popis: | SummaryMast cell-derived prostaglandin D2 (PGD2) is the major prostanoid found within the airway of asthmatics immediately following allergen challenge. PGD2 has been shown to have chemokinetic effects on eosinophils and T helper type 2 (Th2) cells in vitro. This occurs through the interaction of PGD2 with the G-protein-coupled chemokine receptor homologous molecule expressed on Th2 lymphocytes (CRTH2). The expression of CRTH2 has been shown to be highly selective for Th2 cells. Using flow cytometry we have studied the expression of CRTH2 on T cells in blood and bronchoalveolar lavage fluid in asthmatics and normal subjects. CRTH2 expression was confined to a small percentage of blood T cells in asthmatics (1·8% ± 0·2) and normal (1·6% ± 0·2) subjects. CRTH2 was enriched significantly on interleukin (IL)-4+/IL-13+ T cells compared to interferon (IFN)-γ+ T cells (P |
| Databáze: | OpenAIRE |
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