Comparison of the Actim Partus test and the fetal fibronectin test in the prediction of spontaneous preterm birth in symptomatic women undergoing cervical length measurement

Autor: Patrick M.M. Bossuyt, Krystyna M. Sollie, Martijn A. Oudijk, Martina Porath, Femke F. Wilms, Antoinette C. Bolte, Hubertina C.J. Scheepers, Jim van Eyck, Jérôme Cornette, Maureen T.M. Franssen, Kitty W.M. Bloemenkamp, Joris A. M. van der Post, Guid Oei, Gert Jan Van Baaren, Johannes J. Duvekot, Jolande Y. Vis, Brent C. Opmeer, Ben W.J. Mol, Caroline J. Bax, Marjolein Kok, Frank P.H.A. Vandenbussche, Mallory Woiski, Monique C. Haak, Anneke Kwee, Marc E. A. Spaanderman, Merel Bruijn, Bas Nij Bijvank
Přispěvatelé: Obstetrie & Gynaecologie, RS: GROW - R4 - Reproductive and Perinatal Medicine, MUMC+: MA Medische Staf Obstetrie Gynaecologie (9), Reproductive Origins of Adult Health and Disease (ROAHD), Other departments, Obstetrics and Gynaecology, Epidemiology and Data Science, Clinical Research Unit, Obstetrics & Gynecology
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Adult
medicine.medical_specialty
Cervix Uteri
Sensitivity and Specificity
Diagnostic accuracy
SECRETIONS
03 medical and health sciences
DELIVERY
0302 clinical medicine
Obstetric Labor
Premature
Obstetrics and gynaecology
Predictive Value of Tests
Pregnancy
Positive predicative value
Obstetrics and Gynaecology
Journal Article
Medicine
Humans
Comparative Study
030212 general & internal medicine
LABOR
Cervical length
Gynecology
030219 obstetrics & reproductive medicine
Fetal fibronectin
business.industry
Obstetrics
Other Research Radboud Institute for Health Sciences [Radboudumc 0]
Infant
Newborn
Obstetrics and Gynecology
Gestational age
Preterm birth
Actim Partus
Cervical Length Measurement
Test (assessment)
Fibronectins
FACTOR-BINDING PROTEIN-1
Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10]
Reproductive Medicine
Premature Birth
Female
business
Prediction
Cohort study
Zdroj: European Journal of Obstetrics & Gynecology and Reproductive Biology, 206, 220-224. Elsevier
European journal of obstetrics gynecology and reproductive biology, 206, 220-224. ELSEVIER SCIENCE BV
European journal of obstetrics, gynecology, and reproductive biology, 206, 220-224. Elsevier Ireland Ltd
European Journal of Obstetrics, Gynecology and Reproductive Biology, 206, 220-224. Elsevier Ireland Ltd
European Journal of Obstetrics & Gynecology and Reproductive Biology, 206, pp. 220-224
European Journal of Obstetrics, Gynecology and Reproductive Biology, 206, 220. Elsevier Ireland Ltd
European Journal of Obstetrics & Gynecology and Reproductive Biology, 206, 220-224
European Journal of Obstetrics and Gynecology and Reproductive Biology, 206, 220-224
ISSN: 0301-2115
Popis: Contains fulltext : 172184.pdf (Publisher’s version ) (Closed access) OBJECTIVE: To compare the accuracy of the Actim Partus test and fetal fibronectin (fFN) test in the prediction of spontaneous preterm delivery within seven days in symptomatic women undergoing cervical length measurement. STUDY DESIGN: We performed a post-hoc analysis on frozen samples of a nationwide cohort study in all 10 perinatal centres in the Netherlands. We selected samples from women with signs of preterm labour between 24 and 34 weeks of gestational age and a cervical length below 30mm. Delivery within seven days after initial assessment was the primary endpoint. We calculated sensitivity, specificity, and positive and negative predictive values for the combination of both the Actim Partus test and fFN test with cervical length. A test was considered positive in case of a cervical length between 15 and 30mm with a positive Actim Partus or fFN test, and a cervical length below 15mm regardless the test result. RESULTS: In total, samples of 350 women were tested, of whom 69 (20%) delivered within seven days. Eighty-four women had a positive Actim Partus test and 162 women a positive fFN test, of whom 54 (64%) and 63 (39%) delivered within seven days, respectively. Ninety-seven women had a cervical length below 15mm, of whom 50 (52%) delivered within seven days. Sensitivity, specificity, positive and negative predictive values of combining cervical length with the Actim Partus test or the fFN test were 91%, 75%, 47% and 97%, and 96%, 58%, 36% and 98%, respectively. CONCLUSION: According to this post-hoc study, in combination with cervical length, the Actim Partus test could be used as an alternative for the fFN test to identify women who will not deliver within seven days after presentation. Further evidence should be collected in a prospective comparative study.
Databáze: OpenAIRE
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