Pallidal index on MRI as a target organ dose of manganese: structural equation model analysis
| Autor: | Yong Chul Shin, Kyoo Sang Kim, Eun-A Kim, Young-Woo Jin, Sung-Il Cho, Joon Sakong, Seong-Kyu Kang, Yang-Ho Kim, Jung Sun Yang, Hae-Kwan Cheong |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Physiology Mineralogy chemistry.chemical_element Manganese Neuropsychological Tests Toxicology Globus Pallidus Structural equation modeling Memory Occupational Exposure medicine Accidents Occupational Humans Attention Inhalation exposure Behavior Inhalation Exposure medicine.diagnostic_test Chemistry General Neuroscience Manganese Poisoning Magnetic resonance imaging Middle Aged Magnetic Resonance Imaging Ambient air Affect Cross-Sectional Studies Socioeconomic Factors Internal dose Blood manganese level Regression Analysis Target organ Psychomotor Performance |
| Zdroj: | Neurotoxicology. 26(3) |
| ISSN: | 0161-813X |
| Popis: | We have used a structural equation model (SEM) to analyze the interrelationships among exposure markers, magnetic resonance imaging (MRI) signal index, and neurobehavioral effects. Based on exposure groups, we assessed blood manganese, MRI measurements of pallidal index (PI), and neurobehavioral core test battery (WHO-NCTB) on 111 male workers occupationally exposed to manganese, including welders, smelter workers, and welding rod manufacturing workers. Latent variables were constructed to represent the neurobehavioral effects in an integrated way. The structural equation model revealed that airborne manganese and blood manganese contribute to PI significantly. Manganese exposure in the ambient air may lead to an increase in the internal dose, not only indirectly, by increasing blood manganese level, but also directly, independent of blood concentration. PI significantly contributed to a decrease in neurobehavioral test scores. We found that airborne manganese contributed to PI, and that PI is the most effective predictor of neurobehavioral performance, after adjusting for age and level of education. In conclusion, PI on MRI reflects target organ dose of occupational manganese exposure. |
| Databáze: | OpenAIRE |
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