Isolation and structure elucidation of a novel product of the acidic degradation of cefaclor
| Autor: | Leslie J. Lorenz, John L. Occolowitz, Steven W. Baertschi, Marvin Emanuel Wildfeuer, Monte W. Collins, Douglas E. Dorman, Larry A. Spangle |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Cephem
Aqueous solution Chromatography Magnetic Resonance Spectroscopy Spectrophotometry Infrared Pharmaceutical Science Hydrochloric acid Spectrometry Mass Fast Atom Bombardment High-performance liquid chromatography chemistry.chemical_compound chemistry polycyclic compounds medicine Organic chemistry Spectrophotometry Ultraviolet Hydrochloric Acid Cefaclor Thiazole Chromatography High Pressure Liquid Cephalosporin Antibiotic Antibacterial agent medicine.drug |
| Zdroj: | Journal of pharmaceutical sciences. 82(6) |
| ISSN: | 0022-3549 |
| Popis: | The acidic aqueous degradation of cefaclor, an orally administered cephalosporin antibiotic, has been investigated. The most prominent peak in the high-performance liquid chromatography profile of a degraded solution of cefaclor was isolated by preparative high-performance liquid chromatography. Mechanistically, the formation of this degradent from cefaclor involves a condensation of two cefaclor degradation products in which both products have undergone contraction from a six-membered cephem ring to a five-membered thiazole ring, presumably via a common episulfonium ion intermediate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text