Polymorphisms in the interleukin-1 gene influence the stratum corneum interleukin-1 alpha concentration in uninvolved skin of patients with chronic irritant contact dermatitis

T) and IL1B-31 (T-->C) and the concentration of IL-1 alpha and IL-1 ra in the stratum corneum (SC). METHOD: In 124 patients with chronic irritant contact dermatitis, we genotyped the IL1A-889 and IL1B-31 polymorphisms and determined the amount of IL-1 alpha and IL-1 ra on tape strips obtained from uninvolved skin of the volar forearm. RESULTS: The SC IL-1 alpha concentration was 23% and 47% lower in subjects with IL1A-889 C/T genotype and T/T genotype, respectively, compared with wild-type genotype. In subjects with IL1B-31 C/C genotype, the IL-1 alpha concentration was 51% lower compared with C/T and T/T genotypes. The ratio IL-1 ra/IL-1 alpha increased twofold in IL1A-889 C/T genotype and threefold in T/T genotype compared with wild type. CONCLUSIONS: We have shown a clear effect of IL1 genotype on protein expression in the SC. This altered expression may be responsible for the interindividual differences in the inflammatory response of the skin -->
Jazyk: English
ISSN: 0105-1873
DOI: 10.1111/j.1600-0536.2007.01316.x
Přístupová URL adresa: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de40778993d3e05a75afcd63dc9906e6
https://pure.amc.nl/en/publications/polymorphisms-in-the-interleukin1-gene-influence-the-stratum-corneum-interleukin1-alpha-concentration-in-uninvolved-skin-of-patients-with-chronic-irritant-contact-dermatitis(7d38e8c2-3d62-4856-88b0-de82c95b5359).html
Rights: RESTRICTED
Přírůstkové číslo: edsair.doi.dedup.....de40778993d3e05a75afcd63dc9906e6
Autor: Swen M. John, Thomas Rustemeyer, Maarten M. Verberk, Liubov Khrenova, Sanja Kezic, Cindy M. de Jongh
Přispěvatelé: APH - Amsterdam Public Health, Coronel Institute of Occupational Health, Dermatology, CCA - Immuno-pathogenesis
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Zdroj: Contact dermatitis, 58(5), 263-268. Wiley-Blackwell
de Jongh, C M, Khrenova, L, Kezic, S, Rustemeyer, T, Verberk, M M & John, S M 2008, ' Polymorphisms in the interleukin-1 gene influence the stratum corneum interleukin-1 alpha concentration in uninvolved skin of patients with chronic irritant contact dermatitis ', Contact Dermatitis, vol. 58, no. 5, pp. 263-268 . https://doi.org/10.1111/j.1600-0536.2007.01316.x
Contact Dermatitis, 58(5), 263-268. Wiley-Blackwell
ISSN: 0105-1873
DOI: 10.1111/j.1600-0536.2007.01316.x
Popis: BACKGROUND: Interleukin (IL)-1 alpha and its receptor antagonist IL-1 ra play a role in skin inflammation. Several polymorphisms in the IL1 gene cluster, coding for IL-1 alpha, IL-1 ra, and IL-1 beta, influence their protein expression. Within this cluster, strong linkage disequilibrium has been shown. OBJECTIVE: We studied the association between the polymorphisms IL1A-889 (C-->T) and IL1B-31 (T-->C) and the concentration of IL-1 alpha and IL-1 ra in the stratum corneum (SC). METHOD: In 124 patients with chronic irritant contact dermatitis, we genotyped the IL1A-889 and IL1B-31 polymorphisms and determined the amount of IL-1 alpha and IL-1 ra on tape strips obtained from uninvolved skin of the volar forearm. RESULTS: The SC IL-1 alpha concentration was 23% and 47% lower in subjects with IL1A-889 C/T genotype and T/T genotype, respectively, compared with wild-type genotype. In subjects with IL1B-31 C/C genotype, the IL-1 alpha concentration was 51% lower compared with C/T and T/T genotypes. The ratio IL-1 ra/IL-1 alpha increased twofold in IL1A-889 C/T genotype and threefold in T/T genotype compared with wild type. CONCLUSIONS: We have shown a clear effect of IL1 genotype on protein expression in the SC. This altered expression may be responsible for the interindividual differences in the inflammatory response of the skin
Databáze: OpenAIRE
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