Outcome of pandemic H1N1 infections in hematopoietic stem cell transplant recipients
| Autor: | M. Jimena Cannata-Ortiz, Rafael de la Cámara, Jörg Halter, Gülsan Türköz Sucak, Rodrigo Martino, Dan Engelhard, Katherine N. Ward, Lena Pérez-Bercoff, Catherine Cordonnier, Ildefonso Espigado, Andrew J. Ullmann, Hermann Einsele, Per Ljungman, Bilal Mohty, Lourdes Vázquez, Manuel Abecasis, Marta González-Vicent, Jose Bartolo Nieto Campuzano |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Oseltamivir Adolescent medicine.medical_treatment Hematopoietic stem cell transplantation Neutropenia medicine.disease_cause Antiviral Agents Young Adult chemistry.chemical_compound Influenza A Virus H1N1 Subtype Zanamivir Risk Factors Lymphopenia Internal medicine Influenza Human medicine Influenza A virus Humans Young adult Child Prospective cohort study Pandemics Aged business.industry pandemic Vaccination H1N1 Hematopoietic Stem Cell Transplantation virus diseases Pneumonia Hematology Middle Aged medicine.disease Treatment Outcome chemistry Child Preschool HSCT Immunology Brief Reports influenza business medicine.drug |
| Zdroj: | HAEMATOLOGICA r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 1592-8721 0390-6078 |
| DOI: | 10.3324/haematol.2011.041913 |
| Popis: | During 2009, a new strain of A/H1N1 influenza appeared and became pandemic. A prospective study was performed to collect data regarding risk factors and outcome of A/H1N1 in hematopoietic stem cell transplant recipients. Only verified pandemic A/H1N1 influenza strains were included: 286 patients were reported, 222 allogeneic and 64 autologous recipients. The median age was 38.3 years and the median time from transplant was 19.4 months. Oseltamivir was administered to 267 patients and 15 patients received zanamivir. One hundred and twenty-five patients (43.7%) were hospitalized. Ninety-three patients (32.5%) developed lower respiratory tract disease. In multivariate analysis, risk factors were age (OR 1.025; 1.01-1.04; P=0.002) and lymphopenia (OR 2.49; 1.33-4.67; P |
| Databáze: | OpenAIRE |
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