Effects of Aminoguanidine on Lipid and Protein Oxidation in Diabetic Rat Kidneys
| Autor: | Ahmet Yalçin, Sema Akalin, Dilek Gogas-Yavuz, Kaya Emerk, Halil Önder Ersöz, Belgin Küçükkaya |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Kidney Cortex Thiobarbituric acid Endocrinology Diabetes and Metabolism Kidney Nitric Oxide Protein oxidation Guanidines Thiobarbituric Acid Reactive Substances Diabetes Mellitus Experimental Nitric oxide Lipid peroxidation chemistry.chemical_compound Endocrinology Glycation Internal medicine medicine TBARS Albuminuria Animals Diabetic Nephropathies Rats Wistar Proteins Lipid metabolism Lipid Metabolism Streptozotocin Rats chemistry Female Lipid Peroxidation Oxidation-Reduction Research Article medicine.drug |
| Zdroj: | International journal of experimental diabetes research |
| ISSN: | 1560-4284 |
| Popis: | Nonenzymatic glycation of tissue and plasma proteins may stimulate the production of oxidant and carbonyl stress in diabetes. The aim of this study was to evaluate the effects of aminoguanidine (AG) on lipid peroxidation, protein oxidation and nitric oxide (NO) release in diabetic rat kidneys. After induction of diabetes with streptozotocin, female Wistar rats were divided into 2 groups. Group DAG (n=9) rats were given AG hydrogen carbonate (1 g/L) in drinking water and group D (n=8) was diabetic control rats given only tap water. Group H (n=8) was followed as healthy controls. At the end of an 8 week period, NO release, lipid and protein oxidation were determined in kidney tissues. NO release was significantly lower in diabetic rats compared with healthy controls (pAlthough AG treatment had no effect on NO release, it significantly decreased lipid peroxidation in diabetic rat cortices. Consequently increased lipid peroxidation -as well as- protein oxidation could be involved in the pathogenesis of diabetic albuminuria. |
| Databáze: | OpenAIRE |
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