A simplified acute physiology score in the prediction of acute organophosphate poisoning outcome in an intensive care unit
| Autor: | Alireza Salimi, Shahin Shadnia, Abdolkarim Pajoumand, Mohammad Abdollahi, D. Darabi |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Health Toxicology and Mutagenesis medicine.medical_treatment Endotracheal intubation Iran Toxicology Organophosphate poisoning Severity of Illness Index law.invention 03 medical and health sciences 0302 clinical medicine Organophosphate Poisoning law Predictive Value of Tests Intensive care Epidemiology medicine Health Status Indicators Humans Hospital Mortality Prospective Studies Simplified Acute Physiology Score Pesticides Intensive care medicine Aged Mechanical ventilation 030102 biochemistry & molecular biology business.industry Poisoning General Medicine Middle Aged medicine.disease Intensive care unit Intensive Care Units Treatment Outcome SAPS II 030220 oncology & carcinogenesis Case-Control Studies Emergency medicine Female business |
| Zdroj: | Humanexperimental toxicology. 26(8) |
| ISSN: | 0960-3271 |
| Popis: | Organophosphate poisoning (OPP) occurs frequently and accounts for a large number of intoxication cases treated in intensive care units (ICU). Poisoning by these agents is a serious public health problem. Among pesticides, OPs are the main cause of poisoning and death in Loghman-Hakim Poison Center of Tehran, Iran. The aim of this study was to determine the impact of the Simplified Acute Physiology Score (SAPS II) in the prediction of mortality in patients with acute OPP requiring admission to the ICU of Loghman-Hakim Hospital Poison Center over a period of 12 months. This study was a prospective, case-control of records of patients with acute OPP admitted to the ICU between January 2006 and December 2006. The Demographic data were collected and SAPS II score was recorded. During the study period, 24 subjects were admitted to the ICU with acute OPP. All 24 patients (15 male) required endotracheal intubation and mechanical ventilation in addition to gastric decontamination and standard therapy with atropine and oximes and adequate hydration. Of these, 24 patients, eight (five male) died. SAPS II score was significantly higher in the non-survival group than the survival group. Mortality following acute OPP remains high despite adequate intensive care and specific therapy with atropine and oximes. One-third of the subjects needing intensive care die within the hospitalization period. SAPS II scores calculated within the first 24 hours were recognized as good prognostic indicator among patients with acute OPP that required ICU admission. It is concluded that SAPS II score above 11 within the first 24 hours is a predictor of poor outcome in patients with acute OPP requiring ICU admission. Human & Experimental Toxicology (2007) 26, 623—627 |
| Databáze: | OpenAIRE |
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