Long-term safety of anti-TNF-α in PsA patients with concomitant HCV infection: a retrospective observational multicenter study on 15 patients
| Autor: | Costa L, Caso F, Atteno M, Giannitti C, Spadaro A, Ramonda R, Vezz? M, Fiocco U, Galeazzi M, Punzi L, SCARPA, RAFFAELE, COSTA, LUISA, DEL PUENTE, ANTONIO, MORISCO, FILOMENA |
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| Přispěvatelé: | Costa, L, Caso, F, Atteno, M, Giannitti, C, Spadaro, A, Ramonda, R, Vezz?, M, DEL PUENTE, Antonio, Morisco, Filomena, Fiocco, U, Galeazzi, M, Punzi, L, Scarpa, Raffaele, Costa, Luisa, Caso, Francesco, Atteno, Mariangela, Giannitti, Chiara, Spadaro, Antonio, Ramonda, Roberta, Vezzù, Maristella, Del Puente, Antonio, Fiocco, Ugo, Galeazzi, Mauro, Punzi, Leonardo |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Time Factors Inflammatory arthritis Arthritis medicine.disease_cause Gastroenterology Receptors Tumor Necrosis Factor Etanercept Retrospective Studie Antirheumatic Agent Anti-TNF-α Alanine Transaminase General Medicine Middle Aged Viral Load Hepatitis C HCV infection Antirheumatic Agents Biological Product Female Viral load Human medicine.drug medicine.medical_specialty Time Factor Hepatitis C virus Antibodies Monoclonal Humanized Psoriatic arthritis Rheumatology Internal medicine medicine Adalimumab Humans Aspartate Aminotransferases Aged Retrospective Studies Inflammation Biological Products Tumor Necrosis Factor-alpha business.industry Psoriatic arthriti Arthritis Psoriatic Aspartate Aminotransferase medicine.disease Immunoglobulin G Concomitant Immunology business |
| Zdroj: | Europe PubMed Central |
| Popis: | Psoriatic arthritis (PsA) is an inflammatory arthropathy associated with skin and/or nail psoriasis. TNF-α, in addition to its pro-inflammatory role, is an essential cytokine for the host's defense, and its depletion by treatment may facilitate the risk of viral infections or their reactivation. The aim of this study was to evaluate the efficacy and safety of TNF-α blockers in PsA patients with concurrent hepatitis C virus (HCV) infection. This is a multicenter study carried out in four Italian centers specialized in the diagnosis and treatment of PsA. At baseline and after 6 (T6) and 12 months (T12) of therapy, data concerning PsA activity and liver tests were registered. A total of 15 PsA patients with concomitant HCV infection were included in the study. At baseline, 13 patients had low viral load, and liver enzyme tests were within the normal range. During the observation period, these values remained stable. On the other hand, at baseline, a high viral load with slightly increased values of AST and ALT was detected in one patient. At T6 and T12, these values decreased. The remaining patient, at baseline, had low viral load, but with slightly increased AST and ALT values that normalized during the observation period. This is the greatest sample size available in the literature on this topic. The data suggests that anti-TNF-α agents are effective and safe in PsA patients with concomitant HCV. We suggest that the use of anti-TNF-α agents, accompanied by close monitoring, could be a therapeutic option. |
| Databáze: | OpenAIRE |
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