Impact of total splenectomy on peripheral lymphocytes and their subsets in patients with hypersplenism associated with cirrhotic portal hypertension
| Autor: | Jinfang Zheng, Hongfei Wu, Jincai Wu, Wan Yee Lau, Min Zeng, Yunfu Lv |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Liver Cirrhosis Male Cell biology medicine.medical_specialty CD3 Lymphocyte Science Immunology Gastroenterology Article Hypersplenism Immune system Internal medicine Hypertension Portal medicine Humans In patient Lymphocyte Count Multidisciplinary biology Cluster of differentiation business.industry Middle Aged medicine.disease Lymphocyte Subsets Peripheral medicine.anatomical_structure biology.protein Portal hypertension Medicine Female Disease Susceptibility business Biomarkers CD8 |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-6 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | To study the impact of total splenectomy (TS) on peripheral lymphocytes and their subsets in patients with hypersplenism associated with cirrhotic portal hypertension (CPH). We studied 102 consecutive patients who received TS from January 2008 to January 2020 due to CPH-related hypersplenism. A similar number of healthy individuals are used as healthy controls (HC). The total lymphocyte counts and their percentages of B lymphocytes, total T lymphocytes (cluster of differentiation (CD)3+) and their subsets (CD4+, CD8+), and natural killer (NK) cells in preoperative peripheral blood samples in hypersplenism patients were significantly lower than that of the HCs (both P P P > 0.05). However, the percentages of CD3+ cells was significantly higher 1 month after than before surgery (P +, and CD8+ T lymphocytes were significantly lower 1 week after surgery (P P +:CD8+ ratio was not significantly different from those before surgery, and 1 week or 1 month after surgery (P > 0.05). Patients with hypersplenism associated with CPH were significantly immunosuppressed preoperatively. After TS, the total lymphocyte count and percentages of B lymphocytes, and total T lymphocytes and their subsets increased significantly, resulting in improved immune functions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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