The effects of phenytoin on the performance of rats in a delayed match-to-place task
| Autor: | Preston E. Garraghty, L. L. Arnold, N. A. Mesnard, Todd M. Mowery, D. L. Samuelson |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
Cultural Studies Phenytoin Social Psychology Water maze Retention interval Hippocampus Spatial memory Discrimination Learning Rats Sprague-Dawley Escape Reaction Orientation Avoidance Learning Reaction Time medicine Animals Applied Psychology Communication Retention Psychology Hippocampal function Frontal Lobe Rats Philosophy Memory Short-Term Anthropology Anesthesia Nmda receptor blockade Conditioning Operant NMDA receptor Anticonvulsants Psychology Neuroscience medicine.drug |
| Zdroj: | Integrative Physiological & Behavioral Science. 40:17-27 |
| ISSN: | 1936-3567 1053-881X |
| DOI: | 10.1007/bf02734185 |
| Popis: | We have shown previously that phenytoin impairs learning in rats in several different behavioral paradigms (Churchill et al., 1998, 2003; Banks et al., 1999). The present study has examined this drug's effects on performance in a delayed match-to-place water maze paradigm developed by Steele and Morris (1999). We find that phenytoin retards performance, but only when the inter-trial interval (ITI) is short (i.e., 15-sec). With longer ITIs (i.e., 20-min, 2-hr), the performance of the phenytoin-treated rats was quite comparable to the controls. We suggest that this pattern of results stems from a disruption of spatial working memory, perhaps due to the effects of the drug on hippocampal function (cf., Churchill et al., 1998, 2003). This disruption is, however, not so profound that consolidation is prevented. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|