Brief cognitive screening instruments for early detection of Alzheimer’s disease: a systematic review
Autor: | Peter Paul De Deyn, Eva Dierckx, Ellen Elisa De Roeck, Sebastiaan Engelborghs |
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Přispěvatelé: | Faculty of Psychology and Educational Sciences, Brain, Body and Cognition, Personality and Psychopathology, Psychopathology and Information Processing in Older Adults, Clinical and Lifespan Psychology, Clinical sciences, Neurology |
Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Screening test Cognitive Neuroscience Early detection Pencil and paper tests Disease Review MMSE lcsh:RC346-429 lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine Cognition Alzheimer Disease medicine Dementia Brief Psychiatric Rating Scale Humans Medical physics Cognitive Dysfunction lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Cognitive screening lcsh:Neurology. Diseases of the nervous system MoCA Medicine(all) Memory clinic Montreal Cognitive Assessment Mild cognitive impairment medicine.disease Mental Status and Dementia Tests MCI 030104 developmental biology Early Diagnosis Neurology Computer tests Neurology (clinical) Human medicine Psychology Alzheimer’s disease 030217 neurology & neurosurgery Geriatric psychiatry |
Zdroj: | Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-14 (2019) Alzheimer's Research & Therapy Alzheimer's research & therapy |
ISSN: | 1758-9193 |
Popis: | Objectives The objective of this systematic review was (1) to give an overview of the available short screening instruments for the early detection of Alzheimer’s disease (AD) and (2) to review the psychometric properties of these instruments. Methods First, a systematic search of titles and abstracts of PubMed and Web of Science was conducted between February and July 2015 and updated in April 2016 and May 2018. Only papers written in English or Dutch were considered. All full-text papers about cognitive screening instruments for the early detection of AD were included, resulting in the identification of 38 pencil and paper tests and 12 computer tests. In a second step, the psychometric quality of these instruments was evaluated. Therefore, the same databases were searched again to identify papers that described the psychometric properties of the instruments meanwhile applying diagnostic criteria for the diagnostic groups included. Results Out of 1454 papers, 96 clearly discussed the psychometric properties of the instruments. Eighty-nine papers discussed pencil and paper tests of which 80 were validated in a memory clinic setting. Based on the number of studies (31 articles) and the sensitivity (84%) and specificity (74%) values, the Montreal Cognitive Assessment (MoCA) seems to be a promising (pencil and paper) screening test for memory clinic testing as well as for population screening. Regarding computer tests, validation studies were only available for 7 out of 12 tests. Conclusions A large number of screening tests for AD are available. However, most tests are only validated in a memory clinic setting and description of the psychometric properties of the instruments is limited. Especially, computer tests require further research. The MoCA is a promising instrument, but the specificity to detect early AD is rather low. Electronic supplementary material The online version of this article (10.1186/s13195-019-0474-3) contains supplementary material, which is available to authorized users. |
Databáze: | OpenAIRE |
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