Brief cognitive screening instruments for early detection of Alzheimer’s disease: a systematic review

Autor: Peter Paul De Deyn, Eva Dierckx, Ellen Elisa De Roeck, Sebastiaan Engelborghs
Přispěvatelé: Faculty of Psychology and Educational Sciences, Brain, Body and Cognition, Personality and Psychopathology, Psychopathology and Information Processing in Older Adults, Clinical and Lifespan Psychology, Clinical sciences, Neurology
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
medicine.medical_specialty
Screening test
Cognitive Neuroscience
Early detection
Pencil and paper tests
Disease
Review
MMSE
lcsh:RC346-429
lcsh:RC321-571
03 medical and health sciences
0302 clinical medicine
Cognition
Alzheimer Disease
medicine
Dementia
Brief Psychiatric Rating Scale
Humans
Medical physics
Cognitive Dysfunction
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Cognitive screening
lcsh:Neurology. Diseases of the nervous system
MoCA
Medicine(all)
Memory clinic
Montreal Cognitive Assessment
Mild cognitive impairment
medicine.disease
Mental Status and Dementia Tests
MCI
030104 developmental biology
Early Diagnosis
Neurology
Computer tests
Neurology (clinical)
Human medicine
Psychology
Alzheimer’s disease
030217 neurology & neurosurgery
Geriatric psychiatry
Zdroj: Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-14 (2019)
Alzheimer's Research & Therapy
Alzheimer's research & therapy
ISSN: 1758-9193
Popis: Objectives The objective of this systematic review was (1) to give an overview of the available short screening instruments for the early detection of Alzheimer’s disease (AD) and (2) to review the psychometric properties of these instruments. Methods First, a systematic search of titles and abstracts of PubMed and Web of Science was conducted between February and July 2015 and updated in April 2016 and May 2018. Only papers written in English or Dutch were considered. All full-text papers about cognitive screening instruments for the early detection of AD were included, resulting in the identification of 38 pencil and paper tests and 12 computer tests. In a second step, the psychometric quality of these instruments was evaluated. Therefore, the same databases were searched again to identify papers that described the psychometric properties of the instruments meanwhile applying diagnostic criteria for the diagnostic groups included. Results Out of 1454 papers, 96 clearly discussed the psychometric properties of the instruments. Eighty-nine papers discussed pencil and paper tests of which 80 were validated in a memory clinic setting. Based on the number of studies (31 articles) and the sensitivity (84%) and specificity (74%) values, the Montreal Cognitive Assessment (MoCA) seems to be a promising (pencil and paper) screening test for memory clinic testing as well as for population screening. Regarding computer tests, validation studies were only available for 7 out of 12 tests. Conclusions A large number of screening tests for AD are available. However, most tests are only validated in a memory clinic setting and description of the psychometric properties of the instruments is limited. Especially, computer tests require further research. The MoCA is a promising instrument, but the specificity to detect early AD is rather low. Electronic supplementary material The online version of this article (10.1186/s13195-019-0474-3) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje