Hepatic Cryotherapy: Double-Freeze Cycles Achieve Greater Hepatocellular Injury in Man
| Autor: | G.J. Stewart, David L. Morris, A. Preketes, Matthew Horton, William Ross |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
biology Hepatic cryotherapy business.industry medicine.medical_treatment Liver Neoplasms Urology Aspartate transaminase Cryotherapy General Medicine digestive system diseases General Biochemistry Genetics and Molecular Biology Cryosurgery Surgery Liver biology.protein Humans Medicine Secondary tumors Aspartate Aminotransferases Hepatocellular injury General Agricultural and Biological Sciences business Biomarkers |
| Zdroj: | Cryobiology. 32:215-219 |
| ISSN: | 0011-2240 |
| DOI: | 10.1006/cryo.1995.1021 |
| Popis: | Hepatic cryotherapy is a relatively new technique used to treat both primary and secondary tumors. This paper concerns the changes in serum aspartate transaminase (AST) in 45 patients following both single and double freeze with partial thaw cycles. There was considerable elevation in serum AST, greatest on the day of operation, and there was a significantly higher peak AST following the double-freeze cycles (1159; SE, 117.5) compared with single-freeze/thaw procedures (437; SE, 61.7). This finding indicates greater hepatocellular disruption which may be important both in planning clinical hepatic cryosurgery to achieve adequate destruction and also to avoid the morbidity of the cryoshock phenomenon. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect