Nucleus accumbens shell: A potential target for drug-resistant epilepsy with neuropsychiatric disorders
| Autor: | Songtao Qi, Hongxiao Wang, Kaijun Yang, Kewan Wang, Henghui Zhang, Jun Wang, Hao Long, Yuzhen Zhang, Dadi Qian |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Drug Resistant Epilepsy Deep brain stimulation Deep Brain Stimulation medicine.medical_treatment Nucleus accumbens urologic and male genital diseases Nucleus Accumbens 03 medical and health sciences Epilepsy 0302 clinical medicine Limbic system medicine Animals Humans In patient Neurons Mechanism (biology) business.industry Ventral striatum Brain medicine.disease 030104 developmental biology medicine.anatomical_structure Pharmaceutical Preparations Neurology Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Epilepsy Research. 164:106365 |
| ISSN: | 0920-1211 |
| DOI: | 10.1016/j.eplepsyres.2020.106365 |
| Popis: | The nucleus accumbens (NAc) is an important component of the ventral striatum, involving motivational and emotional processes, limbic-motor interfaces. Recently, experimental and clinical data have shown that NAc, particularly NAc shell (NAcs), participates in ictogenesis and epileptogensis in drug-resistant epilepsy (DRE). Therefore, we summarize the existing literature on NAcs and potential role in epilepsy, from the bench to the clinic. Connection abnormalities between NAcs and remainings, degeneration of NAc neurons, and an aberrant distribution of neuroactive substances have been reported in patients with DRE. These changes may be underlying the pathophysiological mechanism of the involvement of NAcs in DRE. Furthermore, alterations in NAcs may also be involved in neuropsychiatric disorders in patients with DRE. These observational studies demonstrate the multiple properties of NAcs and the complex relationship between the limbic system and DRE with neuropsychiatric disorders. NAcs can be a potential target for DBS and stereotactic lesioning to manage DRE with neuropsychiatric disorders. Future studies are warranted to further clarify the role of NAcs in epilepsy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect