The activity of dipeptidyl peptidase II and dipeptidyl peptidase IV in mice immunized with type II collagen
| Autor: | Tosiharu Nagatsu, Hisashi Iwata, Kanji Fujita, Masako Hagihara, Takayuki Miura |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty animal structures Ratón Dipeptidyl Peptidase 4 Endocrinology Diabetes and Metabolism Type II collagen Biology Biochemistry Dipeptidyl peptidase Mice Internal medicine Immunopathology medicine Animals Antigens Dipeptidyl-Peptidases and Tripeptidyl-Peptidases chemistry.chemical_classification Arthritis medicine.disease Dipeptidyl-peptidase II Endocrinology Enzyme chemistry Mice Inbred DBA Rheumatoid arthritis Immunization Polyarthritis Collagen |
| Zdroj: | Biochemical Medicine and Metabolic Biology. 48:227-234 |
| ISSN: | 0885-4505 |
| DOI: | 10.1016/0885-4505(92)90069-b |
| Popis: | We investigated the activity of peptidases in the serum of mice with experimental polyarthritis that was induced by the injection of type II collagen, an experimental model of human rheumatoid arthritis. The activity of dipeptidyl peptidase II (DPP II) was increased and that of dipeptidyl peptidase IV (DPP IV) was decreased resulting in the significant increase of the serum DPP II DPP IV ratio in the polyarthritic mice compared with that of controls. These results indicate that the DPP II DPP IV ratio is a novel index of disease activity in mice with collagen-induced polyarthritis and may be useful in assessing the activity of rheumatoid arthritis in humans. |
| Databáze: | OpenAIRE |
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